ethyl 2-(2-((tert-butoxycarbonyl)(pentyl)amino)-6-(3-nitrophenoxy)-9H-purin-9-yl)acetate

Base Information

Chemical Name:ethyl 2-(2-((tert-butoxycarbonyl)(pentyl)amino)-6-(3-nitrophenoxy)-9H-purin-9-yl)acetate
CAS No.:1255652-33-5
Molecular Formula:C₂₅H₃₂N₆O₇
Molecular Weight:528.565
Hs Code.:

Synonyms:ethyl 2-(2-((tert-butoxycarbonyl)(pentyl)amino)-6-(3-nitrophenoxy)-9H-purin-9-yl)acetate

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Chemical Property of ethyl 2-(2-((tert-butoxycarbonyl)(pentyl)amino)-6-(3-nitrophenoxy)-9H-purin-9-yl)acetate

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Technology Process of ethyl 2-(2-((tert-butoxycarbonyl)(pentyl)amino)-6-(3-nitrophenoxy)-9H-purin-9-yl)acetate

There total 6 articles about ethyl 2-(2-((tert-butoxycarbonyl)(pentyl)amino)-6-(3-nitrophenoxy)-9H-purin-9-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 554-84-7
meta-nitrophenol

: 1255652-19-7
ethyl 2-(2-((tert-butoxycarbonyl)(pentyl)amino)-6-chloro-9H-purin-9-yl)acetate

: 1255652-33-5
ethyl 2-(2-((tert-butoxycarbonyl)(pentyl)amino)-6-(3-nitrophenoxy)-9H-purin-9-yl)acetate

Guidance literature:: ethyl 2-(2-((tert-butoxycarbonyl)(pentyl)amino)-6-chloro-9H-purin-9-yl)acetate; With 1,4-diaza-bicyclo[2.2.2]octane; N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 20 ℃; for 1h;

meta-nitrophenol; With N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 20 ℃; for 16h;
DOI:10.1021/ml100224d

Reference yield:

: 1236151-75-9
ethyl 2-(2-((tert-butoxycarbonyl)amino)-6-chloro-9H-purin-9-yl)acetate

: 1255652-33-5
ethyl 2-(2-((tert-butoxycarbonyl)(pentyl)amino)-6-(3-nitrophenoxy)-9H-purin-9-yl)acetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 20 °C / Inert atmosphere

2.1: 1,4-diaza-bicyclo[2.2.2]octane; N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 1 h / 20 °C

2.2: 16 h / 20 °C

With 1,4-diaza-bicyclo[2.2.2]octane; di-isopropyl azodicarboxylate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; dimethyl sulfoxide; 1.1: Mitsunobu reaction;
DOI:10.1021/ml100224d

Reference yield:

: N₉-Boc-2-amino-6-chloropurine

: 1255652-33-5
ethyl 2-(2-((tert-butoxycarbonyl)(pentyl)amino)-6-(3-nitrophenoxy)-9H-purin-9-yl)acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 2 h / 20 °C / Inert atmosphere

2.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 0.25 h / 20 °C / Inert atmosphere

3.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 20 °C / Inert atmosphere

4.1: 1,4-diaza-bicyclo[2.2.2]octane; N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 1 h / 20 °C

4.2: 16 h / 20 °C

With 1,4-diaza-bicyclo[2.2.2]octane; di-isopropyl azodicarboxylate; sodium hydride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; dimethyl sulfoxide; mineral oil; 2.1: Mitsunobu reaction / 3.1: Mitsunobu reaction;
DOI:10.1021/ml100224d