7-<2,3-di-O-benzoyl-6-bromo-6-deoxy-4-O-(2,3-di-O-benzoyl-6-bromo-6-deoxy-β-D-glucopyranosyl)-β-D-glucopyranosyl>theophylline

Base Information

• Chemical Name: 7-<2,3-di-O-benzoyl-6-bromo-6-deoxy-4-O-(2,3-di-O-benzoyl-6-bromo-6-deoxy-β-D-glucopyranosyl)-β-D-glucopyranosyl>theophylline
• CAS No.: 80928-33-2
• Molecular Formula: C₄₇H₄₂Br₂N₄O₁₄
• Molecular Weight: 1046.68
• Mol file: 80928-33-2.mol

Synonyms:7-<2,3-di-O-benzoyl-6-bromo-6-deoxy-4-O-(2,3-di-O-benzoyl-6-bromo-6-deoxy-β-D-glucopyranosyl)-β-D-glucopyranosyl>theophylline

Chemical Property of 7-<2,3-di-O-benzoyl-6-bromo-6-deoxy-4-O-(2,3-di-O-benzoyl-6-bromo-6-deoxy-β-D-glucopyranosyl)-β-D-glucopyranosyl>theophylline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-<2,3-di-O-benzoyl-6-bromo-6-deoxy-4-O-(2,3-di-O-benzoyl-6-bromo-6-deoxy-β-D-glucopyranosyl)-β-D-glucopyranosyl>theophylline

There total 8 articles about 7-<2,3-di-O-benzoyl-6-bromo-6-deoxy-4-O-(2,3-di-O-benzoyl-6-bromo-6-deoxy-β-D-glucopyranosyl)-β-D-glucopyranosyl>theophylline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

7-<2,3-di-O-benzoyl-4-O-(2,3-di-O-benzoyl-β-D-glucopyranosyl)-β-D-glucopyranosyl>theophylline (80928-32-1) → 7-<2,3-di-O-benzoyl-6-bromo-6-deoxy-4-O-(2,3-di-O-benzoyl-6-bromo-6-deoxy-β-D-glucopyranosyl)-β-D-glucopyranosyl>theophylline (80928-33-2)

Guidance literature:

With N-Bromosuccinimide; triphenylphosphine; In N,N-dimethyl-formamide; at 50 ℃; for 20h;

DOI:10.1016/S0008-6215(00)81908-4

Reference yield:

7-β-cellobiosyltheophylline (80928-28-5) → 7-<2,3-di-O-benzoyl-6-bromo-6-deoxy-4-O-(2,3-di-O-benzoyl-6-bromo-6-deoxy-β-D-glucopyranosyl)-β-D-glucopyranosyl>theophylline (80928-33-2)

Guidance literature:

Multi-step reaction with 5 steps

1: 61 percent / ZnCl₂

2: 56 percent / pyridine / 18 h / 70 °C

3: 85 percent / pyridine / 1) 20 h, 4 deg C, 2) 4 h, RT

4: 83 percent / 70percent acetic acid / H₂O / 1) 1 h, 100 deg C, 2) 1 h, 0 deg C

5: 63 percent / N-bromosuccinimide, triphenylphosphine / dimethylformamide / 20 h / 50 °C

With pyridine; N-Bromosuccinimide; acetic acid; triphenylphosphine; zinc(II) chloride; In water; N,N-dimethyl-formamide;

DOI:10.1016/S0008-6215(00)81908-4

Reference yield:

7-<4-O-(4,6-O-benzylidene-β-D-glucopyranosyl)-β-D-glucopyranosyl>theophylline (80928-29-6) → 7-<2,3-di-O-benzoyl-6-bromo-6-deoxy-4-O-(2,3-di-O-benzoyl-6-bromo-6-deoxy-β-D-glucopyranosyl)-β-D-glucopyranosyl>theophylline (80928-33-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 56 percent / pyridine / 18 h / 70 °C

2: 85 percent / pyridine / 1) 20 h, 4 deg C, 2) 4 h, RT

3: 83 percent / 70percent acetic acid / H₂O / 1) 1 h, 100 deg C, 2) 1 h, 0 deg C

4: 63 percent / N-bromosuccinimide, triphenylphosphine / dimethylformamide / 20 h / 50 °C

With pyridine; N-Bromosuccinimide; acetic acid; triphenylphosphine; In water; N,N-dimethyl-formamide;

DOI:10.1016/S0008-6215(00)81908-4

upstream raw materials:

7-<2,3-di-O-benzoyl-4-O-(2,3-di-O-benzoyl-β-D-glucopyranosyl)-β-D-glucopyranosyl>theophylline

7-β-cellobiosyltheophylline

7-<4-O-(4,6-O-benzylidene-β-D-glucopyranosyl)-β-D-glucopyranosyl>theophylline

7-<4-O-(4,6-O-benzylidene-β-D-glucopyranosyl)-6-O-triphenylmethyl-β-D-glucopyranosyl>theophylline

Downstream raw materials:

7-<2,3-di-O-benzoyl-6-deoxy-4-O-(2,3-di-O-benzoyl-6-deoxy-β-D-glucopyranosyl)-β-D-glucopyranosyl>theophylline