Technology Process of (1S,5R,6S)-5-azido-6-hydroxycyclohex-2-en-1-yl 4-nitrobenzoate
There total 1 articles about (1S,5R,6S)-5-azido-6-hydroxycyclohex-2-en-1-yl 4-nitrobenzoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium azide; cesium chloride heptahydrate;
In
water; acetonitrile;
at 70 ℃;
for 5h;
Reflux;
Inert atmosphere;
DOI:10.1055/s-0031-1290356
- Guidance literature:
-
(1S,5R,6S)-5-azido-6-hydroxycyclohex-2-en-1-yl 4-nitrobenzoate;
With
triphenylphosphine;
In
acetonitrile;
for 2h;
Reflux;
Inert atmosphere;
With
pyridine; acetic acid; triethylamine;
at 20 ℃;
for 6h;
Inert atmosphere;
DOI:10.1055/s-0031-1290356
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: triphenylphosphine / acetonitrile / 2 h / Reflux; Inert atmosphere
1.2: 6 h / 20 °C / Inert atmosphere
2.1: N,N,N′,N′-tetramethylguanidinium azide / acetonitrile / 13 h / 60 °C / Inert atmosphere
3.1: triphenylphosphine / acetonitrile / 3 h / 60 °C / Inert atmosphere
3.2: 2 h / 45 °C / Inert atmosphere
3.3: 2 h / 20 °C / Inert atmosphere
4.1: sodium methylate / methanol / 1 h / 20 °C / Inert atmosphere
4.2: Inert atmosphere
With
sodium methylate; triphenylphosphine; N,N,N′,N′-tetramethylguanidinium azide;
In
methanol; acetonitrile;
DOI:10.1055/s-0031-1290356
