2-butyl-1-(4-(isothiocyanatomethyl)benzyl)-1H-imidazo[4,5-c]quinolin-4-ylamine

Base Information

• Chemical Name: 2-butyl-1-(4-(isothiocyanatomethyl)benzyl)-1H-imidazo[4,5-c]quinolin-4-ylamine
• CAS No.: 1258457-47-4
• Molecular Formula: C₂₃H₂₃N₅S
• Molecular Weight: 401.535

Synonyms:2-butyl-1-(4-(isothiocyanatomethyl)benzyl)-1H-imidazo[4,5-c]quinolin-4-ylamine

Chemical Property of 2-butyl-1-(4-(isothiocyanatomethyl)benzyl)-1H-imidazo[4,5-c]quinolin-4-ylamine

Chemical Property:

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Technology Process of 2-butyl-1-(4-(isothiocyanatomethyl)benzyl)-1H-imidazo[4,5-c]quinolin-4-ylamine

There total 1 articles about 2-butyl-1-(4-(isothiocyanatomethyl)benzyl)-1H-imidazo[4,5-c]quinolin-4-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

carbon disulfide (75-15-0,12122-00-8) + 1-[[4-(aminomethyl)phenyl]methyl]-2-butyl-1H-imidazo[4,5-c]quinolin-4-amine (1258457-59-8) → 2-butyl-1-(4-(isothiocyanatomethyl)benzyl)-1H-imidazo[4,5-c]quinolin-4-ylamine (1258457-47-4)

Guidance literature:

carbon disulfide; 1-[[4-(aminomethyl)phenyl]methyl]-2-butyl-1H-imidazo[4,5-c]quinolin-4-amine; With triethylamine; In dichloromethane; for 1h; Inert atmosphere;

With dmap; di-tert-butyl dicarbonate; In dichloromethane; at 0 ℃; for 18h; Inert atmosphere;

DOI:10.1016/j.bmcl.2010.09.093

Reference yield: 38.0%

(R)-3-((R)-2-amino-3-((S)-3-hydroxy-1-methoxy-1-oxopropan-2-ylamino)-3-oxopropylthio)propane-1,2-diyl dipalmitate (1234473-56-3) + 2-butyl-1-(4-(isothiocyanatomethyl)benzyl)-1H-imidazo[4,5-c]quinolin-4-ylamine (1258457-47-4) → C65H103N7O8S2 (1411774-20-3)

Guidance literature:

With pyridine; at 45 ℃; for 24h;

Reference yield: 22.0%

2-butyl-1-(4-(isothiocyanatomethyl)benzyl)-1H-imidazo[4,5-c]quinolin-4-ylamine (1258457-47-4) + methyl 2-(2-(2-aminoacetamido)acetamido)acetate hydrochloride (39692-67-6) → methyl 1-(4-((4-amino-2-butyl-1H-imidazo[4,5-c]quinolin-1-yl)methyl)phenyl)-6,9-dioxo-3-thioxo-2,4,7,10-tetraazadodecan-12-oate

Guidance literature:

With triethylamine; In methanol; at 45 ℃; for 4h;

DOI:10.1016/j.bmcl.2011.04.050

upstream raw materials:

carbon disulfide

1-[[4-(aminomethyl)phenyl]methyl]-2-butyl-1H-imidazo[4,5-c]quinolin-4-amine

Downstream raw materials:

1-(4-((4-amino-2-butyl-1H-imidazo[4,5-c]quinolin-1-yl)methyl)benzyl)-3-(3-((4-((3-aminopropyl)amino)butyl)amino)propyl)thiourea

C₆₅H₁₀₃N₇O₈S₂

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