N-(3-((1H-benzo[d]imidazol-1-yl)methyl)-4-chlorophenyl)-6-(2-methoxyphenyl)pyrimidin-4-amine

Base Information

Chemical Name:N-(3-((1H-benzo[d]imidazol-1-yl)methyl)-4-chlorophenyl)-6-(2-methoxyphenyl)pyrimidin-4-amine
CAS No.:1569981-75-4
Molecular Formula:C₂₅H₂₀ClN₅O
Molecular Weight:441.92
Hs Code.:

Synonyms:N-(3-((1H-benzo[d]imidazol-1-yl)methyl)-4-chlorophenyl)-6-(2-methoxyphenyl)pyrimidin-4-amine

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Chemical Property of N-(3-((1H-benzo[d]imidazol-1-yl)methyl)-4-chlorophenyl)-6-(2-methoxyphenyl)pyrimidin-4-amine

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Technology Process of N-(3-((1H-benzo[d]imidazol-1-yl)methyl)-4-chlorophenyl)-6-(2-methoxyphenyl)pyrimidin-4-amine

There total 7 articles about N-(3-((1H-benzo[d]imidazol-1-yl)methyl)-4-chlorophenyl)-6-(2-methoxyphenyl)pyrimidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 51-17-2,79351-71-6
benzoimidazole

: 1569986-13-5
(4-chloro-3-chloromethyl-phenyl)-[6-(2-methoxy-phenyl)-pyrimidin-4-yl]-amine

: 1569981-75-4
N-(3-((1H-benzo[d]imidazol-1-yl)methyl)-4-chlorophenyl)-6-(2-methoxyphenyl)pyrimidin-4-amine

Guidance literature:: benzoimidazole; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.5h;

(4-chloro-3-chloromethyl-phenyl)-[6-(2-methoxy-phenyl)-pyrimidin-4-yl]-amine; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 1h;

Reference yield:

: 1569982-08-6
ethyl 2-chloro-5-(6-(2-methoxyphenyl)pyrimidin-4-ylamino)benzoate

: 1569981-75-4
N-(3-((1H-benzo[d]imidazol-1-yl)methyl)-4-chlorophenyl)-6-(2-methoxyphenyl)pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C

2.1: phosphorus trichloride / N,N-dimethyl-formamide; dichloromethane / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

3.2: 1 h / 20 °C

With lithium aluminium tetrahydride; sodium hydride; phosphorus trichloride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 16588-17-3
ethyl ester of 2-chloro-5-nitrobenzoic acid

: 1569981-75-4
N-(3-((1H-benzo[d]imidazol-1-yl)methyl)-4-chlorophenyl)-6-(2-methoxyphenyl)pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 6 steps

1.1: tin(II) chloride dihdyrate; hydrogenchloride / ethanol / 24 h / 20 °C

2.1: triethylamine / isopropyl alcohol / 120 h / Reflux

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / ethanol / 168 h / Inert atmosphere; Reflux

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C

5.1: phosphorus trichloride / N,N-dimethyl-formamide; dichloromethane / 20 °C

6.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

6.2: 1 h / 20 °C

With hydrogenchloride; lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tin(II) chloride dihdyrate; sodium hydride; triethylamine; phosphorus trichloride; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; mineral oil;