BIS THF HNS Derivative 2

Base Information

Chemical Name:BIS THF HNS Derivative 2
CAS No.:799241-85-3
Molecular Formula:C₁₁H₁₃NO₇
Molecular Weight:271.227
Hs Code.:
Mol file:799241-85-3.mol

Synonyms:Carbonic acid 2,5-dioxo-pyrrolidin-1-yl ester (3S,3aS,6aR)-(hexahydro-furo[2,3-b]furan-3-yl) ester

Suppliers and Price of BIS THF HNS Derivative 2

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
1-[[[[(3S,3aS,6aR)-Hexahydrofuro[2,3-b]furan-3-yl]oxy]carbonyl]oxy]-2,5-pyrrolidinedione
2.5mg
$ 160.00

Total 9 raw suppliers

Chemical Property of BIS THF HNS Derivative 2

Chemical Property:

Purity/Quality:

>=99.0% ^*data from raw suppliers

1-[[[[(3S,3aS,6aR)-Hexahydrofuro[2,3-b]furan-3-yl]oxy]carbonyl]oxy]-2,5-pyrrolidinedione ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses 1-[[[[(3S,3aS,6aR)-Hexahydrofuro[2,3-b]furan-3-yl]oxy]carbonyl]oxy]-2,5-pyrrolidinedione is an impurity of TMC114, a bis-THF-derived compound that acts as an HIV-aspartyl protease inhibitor.

Technology Process of BIS THF HNS Derivative 2

There total 3 articles about BIS THF HNS Derivative 2 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 156928-09-5
(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol

: 799241-85-3
Carbonic acid 2,5-dioxo-pyrrolidin-1-yl ester (3S,3aS,6aR)-(hexahydro-furo[2,3-b]furan-3-yl) ester

Guidance literature:: Multi-step reaction with 3 steps

1: DIAD; PPh₃

2: K₂CO₃ / ethanol

3: Et₃N / CH₂Cl₂

With di-isopropyl azodicarboxylate; potassium carbonate; triethylamine; triphenylphosphine; In ethanol; dichloromethane; 1: Mitsunobu reaction;
DOI:10.1021/jm049560p

Reference yield:

: (3S,3aS,6aR)-perhydrofuro[2,3-b]furan-3-yl acetate

: 799241-85-3
Carbonic acid 2,5-dioxo-pyrrolidin-1-yl ester (3S,3aS,6aR)-(hexahydro-furo[2,3-b]furan-3-yl) ester

Guidance literature:: Multi-step reaction with 2 steps

1: K₂CO₃ / ethanol

2: Et₃N / CH₂Cl₂

With potassium carbonate; triethylamine; In ethanol; dichloromethane;
DOI:10.1021/jm049560p