N1-(tert-butoxycarbonyl)-N15-<(benzyloxy)carbonyl>-N15,7-dimethyl-6-oxo-7-azaza-1,15-pentadecanediamine

Base Information

• Chemical Name: N1-(tert-butoxycarbonyl)-N15-<(benzyloxy)carbonyl>-N15,7-dimethyl-6-oxo-7-azaza-1,15-pentadecanediamine
• CAS No.: 214750-82-0
• Molecular Formula: C₂₉H₄₉N₃O₅
• Molecular Weight: 519.725
• Mol file: 214750-82-0.mol

Synonyms:N1-(tert-butoxycarbonyl)-N15-<(benzyloxy)carbonyl>-N15,7-dimethyl-6-oxo-7-azaza-1,15-pentadecanediamine

Chemical Property of N1-(tert-butoxycarbonyl)-N15-<(benzyloxy)carbonyl>-N15,7-dimethyl-6-oxo-7-azaza-1,15-pentadecanediamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N1-(tert-butoxycarbonyl)-N15-<(benzyloxy)carbonyl>-N15,7-dimethyl-6-oxo-7-azaza-1,15-pentadecanediamine

There total 1 articles about N1-(tert-butoxycarbonyl)-N15-<(benzyloxy)carbonyl>-N15,7-dimethyl-6-oxo-7-azaza-1,15-pentadecanediamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-(tert-butoxycarbonylamino)hexanoic acid (6404-29-1) + N'-<(benzyloxy)carbonyl>-N,N'-dimethyl-1,8-octanediamine → N1-(tert-butoxycarbonyl)-N15-<(benzyloxy)carbonyl>-N15,7-dimethyl-6-oxo-7-azaza-1,15-pentadecanediamine (214750-82-0)

Guidance literature:

With chloroformic acid ethyl ester; triethylamine; Yield given; Multistep reaction; 1.) dioxane, 30 min, 2.) dioxane, RT, overnight;

DOI:10.1021/jm981038d

Reference yield:

N1-(tert-butoxycarbonyl)-N15-<(benzyloxy)carbonyl>-N15,7-dimethyl-6-oxo-7-azaza-1,15-pentadecanediamine (214750-82-0) → N1-<(benzyloxy)carbonyl>-7,16-dimethyl-6,17-dioxo-7,16-diaza-1,22-docosanediamine (214750-85-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 75 percent / H₂ / 10 percent Pd/C / methanol / 0.75 h / 775.72 Torr / Ambient temperature

2: 1.) ethyl chlorocarbomate, Et₃N / 1.) dioxane, 30 min, 2.) dioxane, RT, overnight

3: 96 percent / 6N aq. HCl / tetrahydrofuran / 2 h / Ambient temperature

With hydrogenchloride; hydrogen; chloroformic acid ethyl ester; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol;

DOI:10.1021/jm981038d

Reference yield:

N1-(tert-butoxycarbonyl)-N15-<(benzyloxy)carbonyl>-N15,7-dimethyl-6-oxo-7-azaza-1,15-pentadecanediamine (214750-82-0) → N1-(tert-butoxycarbonyl)-N22<(benzyloxy)carbonyl>-7,16-dimethyl-6,17-dioxo-7,16-diaza-1,22-docosanediamine (214750-84-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / H₂ / 10 percent Pd/C / methanol / 0.75 h / 775.72 Torr / Ambient temperature

2: 1.) ethyl chlorocarbomate, Et₃N / 1.) dioxane, 30 min, 2.) dioxane, RT, overnight

With hydrogen; chloroformic acid ethyl ester; triethylamine; palladium on activated charcoal; In methanol;

DOI:10.1021/jm981038d

upstream raw materials:

6-(tert-butoxycarbonylamino)hexanoic acid

Downstream raw materials:

N1-<(benzyloxy)carbonyl>-7,16-dimethyl-6,17-dioxo-7,16-diaza-1,22-docosanediamine

N1-(tert-butoxycarbonyl)-N22<(benzyloxy)carbonyl>-7,16-dimethyl-6,17-dioxo-7,16-diaza-1,22-docosanediamine

N1-<<(5,11-dihydro-6-oxo-6H-pyrido<2,3-b><1,4>benzodiazepin-11-yl)carbonyl>methyl>-N22-<(benzyloxy)carbonyl>-7,16-dimethyl-6,17-dioxo-7,16-diaza-1,22-docosanediamine

N1-<<(5,11-dihydro-6-oxo-6H-pyrido<2,3-b><1,4>benzodiazepin-11-yl)carbonyl>ethyl>-N22-<(benzyloxy)carbonyl>-7,16-dimethyl-6,17-dioxo-7,16-diaza-1,22-docosanediamine