tert-butyl 6-((4-(2-(2-amino-2-oxoethyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-3,4-dihydroisoquinoline-2(1H)-carboxylate

Base Information

Chemical Name:tert-butyl 6-((4-(2-(2-amino-2-oxoethyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-3,4-dihydroisoquinoline-2(1H)-carboxylate
CAS No.:1393901-41-1
Molecular Formula:C₂₉H₃₂F₃N₅O₃
Molecular Weight:555.6
Hs Code.:

Synonyms:tert-butyl 6-((4-(2-(2-amino-2-oxoethyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-3,4-dihydroisoquinoline-2(1H)-carboxylate

Suppliers and Price of tert-butyl 6-((4-(2-(2-amino-2-oxoethyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-3,4-dihydroisoquinoline-2(1H)-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of tert-butyl 6-((4-(2-(2-amino-2-oxoethyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-3,4-dihydroisoquinoline-2(1H)-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of tert-butyl 6-((4-(2-(2-amino-2-oxoethyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-3,4-dihydroisoquinoline-2(1H)-carboxylate

There total 12 articles about tert-butyl 6-((4-(2-(2-amino-2-oxoethyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-3,4-dihydroisoquinoline-2(1H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1393901-40-0
lithium 2-(2-(2-(2-((2-(tert-butoxycarbonyl)-1,2,3,4-tetrahydroisoquinolin-6-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetate

: 1393901-41-1
tert-butyl 6-((4-(2-(2-amino-2-oxoethyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-3,4-dihydroisoquinoline-2(1H)-carboxylate

Guidance literature:: With ammonium carbonate; N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

Reference yield:

: 66370-75-0
methyl (2-iodophenyl)acetate

: 1393901-41-1
tert-butyl 6-((4-(2-(2-amino-2-oxoethyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-3,4-dihydroisoquinoline-2(1H)-carboxylate

Guidance literature:: Multi-step reaction with 8 steps

1.1: triethylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

2.1: tetrabutyl ammonium fluoride / dichloromethane; tetrahydrofuran / 1 h / 0 - 20 °C

3.1: triethylamine / triphenylphosphine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / dichloromethane / 0.17 h / 100 °C / Inert atmosphere; microwave irradiation

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C

5.1: hydrogen / palladium 10% on activated carbon / N,N-dimethyl-formamide / 16 h / 20 °C

6.1: trifluoroacetic acid / 2,2,2-trifluoroethanol / 0.33 h / 100 °C / microwave irradiation

6.2: 18 h

7.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 18 h

8.1: N-ethyl-N,N-diisopropylamine; ammonium carbonate; HATU / N,N-dimethyl-formamide / 18 h / 20 °C

With lithium hydroxide monohydrate; tetrabutyl ammonium fluoride; water; hydrogen; ammonium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; HATU; trifluoroacetic acid; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; palladium 10% on activated carbon; triphenylphosphine; In tetrahydrofuran; dichloromethane; 2,2,2-trifluoroethanol; N,N-dimethyl-formamide;

Reference yield:

: 3932-97-6
2,4-dichloro-5-trifluoromethylpyrimidine

: 1393901-41-1
tert-butyl 6-((4-(2-(2-amino-2-oxoethyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-3,4-dihydroisoquinoline-2(1H)-carboxylate

Guidance literature:: Multi-step reaction with 8 steps

1.1: zinc(II) chloride / diethyl ether; tetrahydrofuran / 2 h / Cooling with ice; Inert atmosphere

1.2: 20 °C

2.1: sodium iodide; hydrogen iodide / 48 h / Darkness

3.1: triethylamine / triphenylphosphine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / dichloromethane / 0.17 h / 100 °C / Inert atmosphere; microwave irradiation

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C

5.1: hydrogen / palladium 10% on activated carbon / N,N-dimethyl-formamide / 16 h / 20 °C

6.1: trifluoroacetic acid / 2,2,2-trifluoroethanol / 0.33 h / 100 °C / microwave irradiation

6.2: 18 h

7.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 18 h

8.1: N-ethyl-N,N-diisopropylamine; ammonium carbonate; HATU / N,N-dimethyl-formamide / 18 h / 20 °C

With lithium hydroxide monohydrate; water; hydrogen iodide; hydrogen; ammonium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; HATU; trifluoroacetic acid; sodium iodide; zinc(II) chloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; palladium 10% on activated carbon; triphenylphosphine; In tetrahydrofuran; diethyl ether; dichloromethane; 2,2,2-trifluoroethanol; N,N-dimethyl-formamide;