N-t-butyl-6-(4-phenyl-1H-1,2,3-triazol-1-yl)-1,2-benzisothiazole-3(2H)-one 1,1-dioxide

Base Information

Chemical Name:N-t-butyl-6-(4-phenyl-1H-1,2,3-triazol-1-yl)-1,2-benzisothiazole-3(2H)-one 1,1-dioxide
CAS No.:1595189-53-9
Molecular Formula:C₁₉H₁₈N₄O₃S
Molecular Weight:382.443
Hs Code.:

Synonyms:N-t-butyl-6-(4-phenyl-1H-1,2,3-triazol-1-yl)-1,2-benzisothiazole-3(2H)-one 1,1-dioxide

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Chemical Property of N-t-butyl-6-(4-phenyl-1H-1,2,3-triazol-1-yl)-1,2-benzisothiazole-3(2H)-one 1,1-dioxide

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Technology Process of N-t-butyl-6-(4-phenyl-1H-1,2,3-triazol-1-yl)-1,2-benzisothiazole-3(2H)-one 1,1-dioxide

There total 5 articles about N-t-butyl-6-(4-phenyl-1H-1,2,3-triazol-1-yl)-1,2-benzisothiazole-3(2H)-one 1,1-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1595189-52-8
N-t-butyl-6-azido-1,2-benzisothiazole-3(2H)-one 1,1-dioxide

: 536-74-3
phenylacetylene

: 1595189-53-9
N-t-butyl-6-(4-phenyl-1H-1,2,3-triazol-1-yl)-1,2-benzisothiazole-3(2H)-one 1,1-dioxide

Guidance literature:: With copper(ll) sulfate pentahydrate; sodium L-ascorbate; In tetrahydrofuran; water; at 40 ℃; for 16h;
DOI:10.1021/jm500255y

Reference yield:

: N-t-butyl-6-nitro-1,2-benzisothiazole-3(2H)-one 1,1-dioxide

: 1595189-53-9
N-t-butyl-6-(4-phenyl-1H-1,2,3-triazol-1-yl)-1,2-benzisothiazole-3(2H)-one 1,1-dioxide

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen; palladium 10% on activated carbon / methanol / 16 h / 20 °C

2: tert.-butylnitrite; trimethylsilylazide / acetonitrile / 7 h / 0 - 20 °C

3: sodium L-ascorbate; copper(ll) sulfate pentahydrate / water; tetrahydrofuran / 16 h / 40 °C

With tert.-butylnitrite; copper(ll) sulfate pentahydrate; trimethylsilylazide; palladium 10% on activated carbon; hydrogen; sodium L-ascorbate; In tetrahydrofuran; methanol; water; acetonitrile;
DOI:10.1021/jm500255y

Reference yield:

: N-(1,1-dimethylethyl)-2-methyl-5-nitrobenzenesulfonamide

: 1595189-53-9
N-t-butyl-6-(4-phenyl-1H-1,2,3-triazol-1-yl)-1,2-benzisothiazole-3(2H)-one 1,1-dioxide

Guidance literature:: Multi-step reaction with 4 steps

1: chromium(VI) oxide; periodic acid; acetic anhydride / acetonitrile / Reflux

2: hydrogen; palladium 10% on activated carbon / methanol / 16 h / 20 °C

3: tert.-butylnitrite; trimethylsilylazide / acetonitrile / 7 h / 0 - 20 °C

4: sodium L-ascorbate; copper(ll) sulfate pentahydrate / water; tetrahydrofuran / 16 h / 40 °C

With chromium(VI) oxide; tert.-butylnitrite; copper(ll) sulfate pentahydrate; trimethylsilylazide; palladium 10% on activated carbon; hydrogen; acetic anhydride; sodium L-ascorbate; periodic acid; In tetrahydrofuran; methanol; water; acetonitrile;
DOI:10.1021/jm500255y