(5-methoxy-4-methyl-2-[1,2,3]triazol-2-ylphenyl)-{(S)-2-[3-(2-trifluoromethoxyphenyl)-[1,2,4]oxadiazol-5-yl]pyrrolidin-1-yl}methanone

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Chemical Name:(5-methoxy-4-methyl-2-[1,2,3]triazol-2-ylphenyl)-{(S)-2-[3-(2-trifluoromethoxyphenyl)-[1,2,4]oxadiazol-5-yl]pyrrolidin-1-yl}methanone
CAS No.:1597519-64-6
Molecular Formula:C₂₄H₂₁F₃N₆O₄
Molecular Weight:514.464
Hs Code.:

Synonyms:(5-methoxy-4-methyl-2-[1,2,3]triazol-2-ylphenyl)-{(S)-2-[3-(2-trifluoromethoxyphenyl)-[1,2,4]oxadiazol-5-yl]pyrrolidin-1-yl}methanone

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Chemical Property of (5-methoxy-4-methyl-2-[1,2,3]triazol-2-ylphenyl)-{(S)-2-[3-(2-trifluoromethoxyphenyl)-[1,2,4]oxadiazol-5-yl]pyrrolidin-1-yl}methanone

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Technology Process of (5-methoxy-4-methyl-2-[1,2,3]triazol-2-ylphenyl)-{(S)-2-[3-(2-trifluoromethoxyphenyl)-[1,2,4]oxadiazol-5-yl]pyrrolidin-1-yl}methanone

There total 5 articles about (5-methoxy-4-methyl-2-[1,2,3]triazol-2-ylphenyl)-{(S)-2-[3-(2-trifluoromethoxyphenyl)-[1,2,4]oxadiazol-5-yl]pyrrolidin-1-yl}methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1429776-75-9
5-methoxy-4-methyl-2-(2H-1 ,2,3-triazol-2-yl)benzoic acid

: 1597528-48-7
5-(S)-pyrrolidin-2-yl-3-(2-trifluoromethoxyphenyl)[1,2,4]oxadiazole

: 1597519-64-6
(5-methoxy-4-methyl-2-[1,2,3]triazol-2-ylphenyl)-{(S)-2-[3-(2-trifluoromethoxyphenyl)-[1,2,4]oxadiazol-5-yl]pyrrolidin-1-yl}methanone

Guidance literature:: 5-methoxy-4-methyl-2-(2H-1 ,2,3-triazol-2-yl)benzoic acid; With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 0.25h; Inert atmosphere;

5-(S)-pyrrolidin-2-yl-3-(2-trifluoromethoxyphenyl)[1,2,4]oxadiazole; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;
DOI:10.1002/cmdc.201900242

Reference yield:

: 7151-68-0
3-methoxy-p-toluic acid

: 1597519-64-6
(5-methoxy-4-methyl-2-[1,2,3]triazol-2-ylphenyl)-{(S)-2-[3-(2-trifluoromethoxyphenyl)-[1,2,4]oxadiazol-5-yl]pyrrolidin-1-yl}methanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: bromine; acetic acid / water / 2 h / 60 °C / Inert atmosphere

2.1: copper(l) iodide; trans-N,N'-dimethylcyclohexane-1,2-diamine; caesium carbonate / N,N-dimethyl-formamide / 1 h / 120 °C

3.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.25 h / 20 °C / Inert atmosphere

3.2: 1 h / 20 °C / Inert atmosphere

With copper(l) iodide; bromine; caesium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; acetic acid; trans-N,N'-dimethylcyclohexane-1,2-diamine; N-ethyl-N,N-diisopropylamine; In dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1002/cmdc.201900242

Reference yield:

: 61809-40-3
2-bromo-5-methoxy-4-methyl-benzoic acid

: 1597519-64-6
(5-methoxy-4-methyl-2-[1,2,3]triazol-2-ylphenyl)-{(S)-2-[3-(2-trifluoromethoxyphenyl)-[1,2,4]oxadiazol-5-yl]pyrrolidin-1-yl}methanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: copper(l) iodide; trans-N,N'-dimethylcyclohexane-1,2-diamine; caesium carbonate / N,N-dimethyl-formamide / 1 h / 120 °C

2.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.25 h / 20 °C / Inert atmosphere

2.2: 1 h / 20 °C / Inert atmosphere

With copper(l) iodide; caesium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; trans-N,N'-dimethylcyclohexane-1,2-diamine; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/cmdc.201900242