2-[3-(4-chlorophenyl)-4,6-dimethoxyindol-2-yl]-2-hydroxy-N-methylethanamide

Base Information

• Chemical Name: 2-[3-(4-chlorophenyl)-4,6-dimethoxyindol-2-yl]-2-hydroxy-N-methylethanamide
• CAS No.: 174416-24-1
• Molecular Formula: C₁₉H₁₉ClN₂O₄
• Molecular Weight: 374.824

Synonyms:2-[3-(4-chlorophenyl)-4,6-dimethoxyindol-2-yl]-2-hydroxy-N-methylethanamide

Chemical Property of 2-[3-(4-chlorophenyl)-4,6-dimethoxyindol-2-yl]-2-hydroxy-N-methylethanamide

Chemical Property:

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Technology Process of 2-[3-(4-chlorophenyl)-4,6-dimethoxyindol-2-yl]-2-hydroxy-N-methylethanamide

There total 2 articles about 2-[3-(4-chlorophenyl)-4,6-dimethoxyindol-2-yl]-2-hydroxy-N-methylethanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

N-methyl-2-(3'-(4''-chlorophenyl)-4',6'-dimethoxyindol-2'-yl)glyoxylamide (180728-69-2) → 2-[3-(4-chlorophenyl)-4,6-dimethoxyindol-2-yl]-2-hydroxy-N-methylethanamide (174416-24-1)

Guidance literature:

With sodium tetrahydroborate; In methanol; for 0.333333h;

DOI:10.1016/S0040-4020(00)00774-2

Reference yield:

3-(4-chlorophenyl)-4,6-dimethoxy-1H-indole (151290-21-0) → 2-[3-(4-chlorophenyl)-4,6-dimethoxyindol-2-yl]-2-hydroxy-N-methylethanamide (174416-24-1)

Guidance literature:

DOI:10.1016/0040-4039(95)02138-8

Reference yield:

2-[3-(4-chlorophenyl)-4,6-dimethoxyindol-2-yl]-2-hydroxy-N-methylethanamide (174416-24-1) → C57H51Cl3N6O9 + C57H51Cl3N6O9

Guidance literature:

With hydrogen cation;

DOI:10.1016/0040-4039(95)02138-8

upstream raw materials:

N-methyl-2-(3'-(4''-chlorophenyl)-4',6'-dimethoxyindol-2'-yl)glyoxylamide

3-(4-chlorophenyl)-4,6-dimethoxy-1H-indole

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