4-(4-Acetyl-piperazin-1-yl)-2-methylaniline

Base Information

• Chemical Name: 4-(4-Acetyl-piperazin-1-yl)-2-methylaniline
• CAS No.: 862686-09-7
• Molecular Formula: C13H19 N3 O
• Molecular Weight: 233.313
• Mol file: 862686-09-7.mol

Synonyms:Piperazine,1-acetyl-4-(4-amino-2-methylphenyl)- (9CI)

Chemical Property of 4-(4-Acetyl-piperazin-1-yl)-2-methylaniline

Chemical Property:

• Vapor Pressure: 1.85E-09mmHg at 25°C
• Refractive Index: 1.589
• Boiling Point: 482.3°C at 760 mmHg
• Flash Point: 245.5°C
• PSA: 49.57000
• Density: 1.151g/cm³
• LogP: 1.82980

Purity/Quality:

97% ^*data from raw suppliers

[4-(4-Acetylpiperazin-1-yl)-3-methylphenyl]amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(4-Acetyl-piperazin-1-yl)-2-methylaniline

There total 4 articles about 4-(4-Acetyl-piperazin-1-yl)-2-methylaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

→ 1-acetyl-4-(4-amino-2-methylphenyl)-piperazine (862686-09-7)

Guidance literature:

Reference yield: 98.0%

1-acetyl-4-(2-methyl-4-nitrophenyl)piperazine (862685-95-8) → 1-acetyl-4-(4-amino-2-methylphenyl)-piperazine (862686-09-7)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In ethanol; at 18 - 25 ℃;

Reference yield:

5-nitro-2-fluorotoluene (455-88-9) → 1-acetyl-4-(4-amino-2-methylphenyl)-piperazine (862686-09-7)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / dimethyl sulfoxide / 4 h / 90 °C

2: nickel(II) chloride hexahydrate; sodium tetrahydroborate / methanol; dichloromethane / 1 h / 0 °C

With sodium tetrahydroborate; nickel(II) chloride hexahydrate; potassium carbonate; In methanol; dichloromethane; dimethyl sulfoxide;

DOI:10.1016/j.bmc.2020.115680

upstream raw materials:

1-acetyl-4-(2-methyl-4-nitrophenyl)piperazine

5-nitro-2-fluorotoluene

N-acetylpiperidine