3-N-BOC-AMINO-3-(4-FLUORO-PHENYL)-PROPAN-1-OL

Base Information

• Chemical Name: 3-N-BOC-AMINO-3-(4-FLUORO-PHENYL)-PROPAN-1-OL
• CAS No.: 862466-16-8
• Molecular Formula: C₁₄H₂₀FNO₃
• Molecular Weight: 269.316
• Hs Code.: 2924299090
• Mol file: 862466-16-8.mol

Synonyms:Carbamic acid,[1-(4-fluorophenyl)-3-hydroxypropyl]-, 1,1-dimethylethyl ester (9CI);tert-Butyl N-[1-(4-fluorophenyl)-3-hydroxy-propyl]carbamate;[1-(4-Fluoro-phenyl)-3-hydroxy-propyl]-carbamic acid tert-butyl ester;

Chemical Property of 3-N-BOC-AMINO-3-(4-FLUORO-PHENYL)-PROPAN-1-OL

Chemical Property:

• Vapor Pressure: 2.22E-07mmHg at 25°C
• Refractive Index: 1.508
• Boiling Point: 407.8 °C at 760 mmHg
• Flash Point: 200.4 °C
• PSA: 58.56000
• Density: 1.14 g/cm³
• LogP: 3.16480
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

3-(Boc-Amino)-3-(4-fluorophenyl)-1-propanol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-N-BOC-AMINO-3-(4-FLUORO-PHENYL)-PROPAN-1-OL

There total 2 articles about 3-N-BOC-AMINO-3-(4-FLUORO-PHENYL)-PROPAN-1-OL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-amino-3-(4-fluorophenyl)propanoic acid (325-89-3) → [1-(4-fluoro-phenyl)-3-hydroxy-propyl]-carbamic acid tert-butyl ester (862466-16-8)

Guidance literature:

Multi-step reaction with 2 steps

1: LAH / tetrahydrofuran

2: CH₂Cl₂

With lithium aluminium tetrahydride; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.bmcl.2005.05.038

Reference yield:

4-fluorobenzaldehyde (459-57-4) → [1-(4-fluoro-phenyl)-3-hydroxy-propyl]-carbamic acid tert-butyl ester (862466-16-8)

Guidance literature:

Multi-step reaction with 3 steps

1: ammonium acetate / ethanol / 16 h / Heating

2: LAH / tetrahydrofuran

3: CH₂Cl₂

With ammonium acetate; lithium aluminium tetrahydride; In tetrahydrofuran; ethanol; dichloromethane;

DOI:10.1016/j.bmcl.2005.05.038

Reference yield:

[1-(4-fluoro-phenyl)-3-hydroxy-propyl]-carbamic acid tert-butyl ester (862466-16-8) → 1-[3-amino-3-(4-fluoro-phenyl)-propyl]-3-(2,6-difluoro-benzyl)-5-(3-methoxy-phenyl)-[1,3,5]triazinane-2,4,6-trione

Guidance literature:

Multi-step reaction with 2 steps

1: PPh₃; di-t-butyl azodicarboxylate / tetrahydrofuran / 5 h

2: TFA / CH₂Cl₂ / 1 h

With di-tert-butyl-diazodicarboxylate; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; 1: Mitsunobu reaction;

DOI:10.1016/j.bmcl.2005.05.038

upstream raw materials:

3-amino-3-(4-fluorophenyl)propanoic acid

4-fluorobenzaldehyde

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