Technology Process of (17E)-3β-benzamidopregn-17(20)-en-16-one
There total 8 articles about (17E)-3β-benzamidopregn-17(20)-en-16-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
benzoic acid;
With
1,1'-carbonyldiimidazole;
In
dichloromethane;
for 2h;
Cooling with ice;
(17E)-3β-aminopregn-17(20)-en-16-one;
In
dichloromethane;
at 20 ℃;
for 24h;
DOI:10.1002/ddr.21157
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: triphenylphosphine / tetrahydrofuran / 1 h / Cooling with ice
1.2: Mitsunobu Displacement / 18 h
2.1: selenium(IV) oxide; tert.-butylhydroperoxide / dichloromethane / 3.5 h / Cooling with ice
3.1: hydrazine hydrate / methanol / 1 h / Reflux
4.1: triethylamine / tetrahydrofuran / 17 h / 20 °C / Cooling with ice
5.1: manganese(IV) oxide / dichloromethane / 2 h / Reflux
6.1: trifluoroacetic acid / dichloromethane / 1 h / Cooling with ice
7.1: 1,1'-carbonyldiimidazole / dichloromethane / 2 h / Cooling with ice
7.2: 24 h / 20 °C
With
tert.-butylhydroperoxide; manganese(IV) oxide; selenium(IV) oxide; hydrazine hydrate; triethylamine; triphenylphosphine; 1,1'-carbonyldiimidazole; trifluoroacetic acid;
In
tetrahydrofuran; methanol; dichloromethane;
1.1: |Mitsunobu Displacement;
DOI:10.1002/ddr.21157
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: manganese(IV) oxide / dichloromethane / 2 h / Reflux
2.1: trifluoroacetic acid / dichloromethane / 1 h / Cooling with ice
3.1: 1,1'-carbonyldiimidazole / dichloromethane / 2 h / Cooling with ice
3.2: 24 h / 20 °C
With
manganese(IV) oxide; 1,1'-carbonyldiimidazole; trifluoroacetic acid;
In
dichloromethane;
DOI:10.1002/ddr.21157
