11H-Pyrido[2,1-b]quinazolin-11-one, 6,7,8,9-tetrahydro-6-[(4-hydroxy-3,5-dimethoxyphenyl)methylene]-4-methoxy-, (6E)-

Base Information

Chemical Name:11H-Pyrido[2,1-b]quinazolin-11-one, 6,7,8,9-tetrahydro-6-[(4-hydroxy-3,5-dimethoxyphenyl)methylene]-4-methoxy-, (6E)-
CAS No.:862080-91-9
Molecular Formula:C₂₂H₂₂N₂O₅
Molecular Weight:394.427
Hs Code.:
Mol file:862080-91-9.mol

Synonyms:11H-Pyrido[2,1-b]quinazolin-11-one, 6,7,8,9-tetrahydro-6-[(4-hydroxy-3,5-dimethoxyphenyl)methylene]-4-methoxy-, (6E)-

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Chemical Property of 11H-Pyrido[2,1-b]quinazolin-11-one, 6,7,8,9-tetrahydro-6-[(4-hydroxy-3,5-dimethoxyphenyl)methylene]-4-methoxy-, (6E)-

Chemical Property:

PSA：82.81000
LogP:3.46230

Purity/Quality:

Safty Information:

Pictogram(s):
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Useful:

Technology Process of 11H-Pyrido[2,1-b]quinazolin-11-one, 6,7,8,9-tetrahydro-6-[(4-hydroxy-3,5-dimethoxyphenyl)methylene]-4-methoxy-, (6E)-

There total 3 articles about 11H-Pyrido[2,1-b]quinazolin-11-one, 6,7,8,9-tetrahydro-6-[(4-hydroxy-3,5-dimethoxyphenyl)methylene]-4-methoxy-, (6E)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 134-96-3
syringic aldehyde

: 4-methoxy-6,7,8,9-tetrahydro-pyrido[2,1-b]quinazolin-11-one

: 862080-91-9
6-(4-hydroxy-3,5-dimethoxy-benzylidene)-4-methoxy-6,7,8,9-tetrahydro-pyrido[2,1-b]quinazolin-11-one

Guidance literature:: With pyridine; at 230 ℃; for 0.2h; microwave irradiation;
DOI:10.1021/ol0513084

Reference yield:

: 3177-80-8
2-amino-3-methoxybenzoic acid

: 862080-91-9
6-(4-hydroxy-3,5-dimethoxy-benzylidene)-4-methoxy-6,7,8,9-tetrahydro-pyrido[2,1-b]quinazolin-11-one

Guidance literature:: Multi-step reaction with 2 steps

1: P(OPh)3; pyridine / 0.17 h / 220 °C / microwave irradiation

2: 0.2 h / 230 °C / microwave irradiation

With pyridine; triphenyl phosphite;
DOI:10.1016/j.bmcl.2005.10.022

Reference yield:

: 27219-07-4
5-(N-tert-butyloxycarbonyl)aminopentanoic acid

: 862080-91-9
6-(4-hydroxy-3,5-dimethoxy-benzylidene)-4-methoxy-6,7,8,9-tetrahydro-pyrido[2,1-b]quinazolin-11-one

Guidance literature:: Multi-step reaction with 2 steps

1: P(OPh)3; pyridine / 0.17 h / 220 °C / microwave irradiation

2: 0.2 h / 230 °C / microwave irradiation

With pyridine; triphenyl phosphite;
DOI:10.1016/j.bmcl.2005.10.022