(1S,2S)-2-[(2S,3R,4S,5R)-4-(3-chloro-2-fluoro-phenyl)-3-(4-chloro-2-fluoro-phenyl)-3-cyano-2-(2,2-dimethyl-propyl)-5-hydroxymethyl-pyrrolidin-1-ylmethyl]-cyclopropanecarboxylic acid

Base Information

Chemical Name:(1S,2S)-2-[(2S,3R,4S,5R)-4-(3-chloro-2-fluoro-phenyl)-3-(4-chloro-2-fluoro-phenyl)-3-cyano-2-(2,2-dimethyl-propyl)-5-hydroxymethyl-pyrrolidin-1-ylmethyl]-cyclopropanecarboxylic acid
CAS No.:1380805-33-3
Molecular Formula:C₂₈H₃₀Cl₂F₂N₂O₃
Molecular Weight:551.461
Hs Code.:

(1S,2S)-2-[(2S,3R,4S,5R)-4-(3-chloro-2-fluoro-phenyl)-3-(4-chloro-2-fluoro-phenyl)-3-cyano-2-(2,2-dimethyl-propyl)-5-hydroxymethyl-pyrrolidin-1-ylmethyl]-cyclopropanecarboxylic acid

Synonyms:(1S,2S)-2-[(2S,3R,4S,5R)-4-(3-chloro-2-fluoro-phenyl)-3-(4-chloro-2-fluoro-phenyl)-3-cyano-2-(2,2-dimethyl-propyl)-5-hydroxymethyl-pyrrolidin-1-ylmethyl]-cyclopropanecarboxylic acid

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Chemical Property of (1S,2S)-2-[(2S,3R,4S,5R)-4-(3-chloro-2-fluoro-phenyl)-3-(4-chloro-2-fluoro-phenyl)-3-cyano-2-(2,2-dimethyl-propyl)-5-hydroxymethyl-pyrrolidin-1-ylmethyl]-cyclopropanecarboxylic acid

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Technology Process of (1S,2S)-2-[(2S,3R,4S,5R)-4-(3-chloro-2-fluoro-phenyl)-3-(4-chloro-2-fluoro-phenyl)-3-cyano-2-(2,2-dimethyl-propyl)-5-hydroxymethyl-pyrrolidin-1-ylmethyl]-cyclopropanecarboxylic acid

There total 3 articles about (1S,2S)-2-[(2S,3R,4S,5R)-4-(3-chloro-2-fluoro-phenyl)-3-(4-chloro-2-fluoro-phenyl)-3-cyano-2-(2,2-dimethyl-propyl)-5-hydroxymethyl-pyrrolidin-1-ylmethyl]-cyclopropanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 12.0%

: 2-[(2S,3R,4S,5R)-4-(3-chloro-2-fluoro-phenyl)-3-(4-chloro-2-fluoro-phenyl)-3-cyano-2-(2,2-dimethyl-propyl)-5-hydroxymethyl-pyrrolidin-1-ylmethyl]-cyclopropanecarboxylic acid ethyl ester

: 1380805-31-1
(1R,2R)-2-[(2S,3R,4S,5R)-4-(3-chloro-2-fluoro-phenyl)-3-(4-chloro-2-fluoro-phenyl)-3-cyano-2-(2,2-dimethyl-propyl)-5-hydroxymethyl-pyrrolidin-1-ylmethyl]-cyclopropanecarboxylic acid

: 1380805-33-3
(1S,2S)-2-[(2S,3R,4S,5R)-4-(3-chloro-2-fluoro-phenyl)-3-(4-chloro-2-fluoro-phenyl)-3-cyano-2-(2,2-dimethyl-propyl)-5-hydroxymethyl-pyrrolidin-1-ylmethyl]-cyclopropanecarboxylic acid

Guidance literature:: With water; lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 4h;

Reference yield:

: 1354693-60-9
rac-(2R,3S,4R,5S)-3-(3-chloro-2-fluoro-phenyl)-4-(4-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-pyrrolidine-2-carboxylic acid methyl ester

: 1380805-31-1
(1R,2R)-2-[(2S,3R,4S,5R)-4-(3-chloro-2-fluoro-phenyl)-3-(4-chloro-2-fluoro-phenyl)-3-cyano-2-(2,2-dimethyl-propyl)-5-hydroxymethyl-pyrrolidin-1-ylmethyl]-cyclopropanecarboxylic acid

: 1380805-33-3
(1S,2S)-2-[(2S,3R,4S,5R)-4-(3-chloro-2-fluoro-phenyl)-3-(4-chloro-2-fluoro-phenyl)-3-cyano-2-(2,2-dimethyl-propyl)-5-hydroxymethyl-pyrrolidin-1-ylmethyl]-cyclopropanecarboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: methanol; sodium tetrahydroborate; lithium chloride / tetrahydrofuran / 20 °C

2: sodium tris(acetoxy)borohydride; acetic acid / 72 h / 20 °C

3: water; lithium hydroxide / tetrahydrofuran / 4 h / 20 °C

With methanol; sodium tetrahydroborate; water; sodium tris(acetoxy)borohydride; acetic acid; lithium chloride; lithium hydroxide; In tetrahydrofuran;

Reference yield:

: 13949-93-4,13950-12-4,77183-91-6,77183-92-7,109716-50-9,109716-61-2,20417-61-2
ethyl-2-formyl-1-cyclopropane carboxylate

: 1380805-27-5
(2S,3R,4S,5R)-4-(3-chloro-2-fluoro-phenyl)-3-(4-chloro-2-fluoro-phenyl)-2-(2,2-dimethyl-propyl)-5-hydroxymethyl-pyrrolidine-3-carbonitrile

: 1380805-31-1
(1R,2R)-2-[(2S,3R,4S,5R)-4-(3-chloro-2-fluoro-phenyl)-3-(4-chloro-2-fluoro-phenyl)-3-cyano-2-(2,2-dimethyl-propyl)-5-hydroxymethyl-pyrrolidin-1-ylmethyl]-cyclopropanecarboxylic acid

: 1380805-33-3
(1S,2S)-2-[(2S,3R,4S,5R)-4-(3-chloro-2-fluoro-phenyl)-3-(4-chloro-2-fluoro-phenyl)-3-cyano-2-(2,2-dimethyl-propyl)-5-hydroxymethyl-pyrrolidin-1-ylmethyl]-cyclopropanecarboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tris(acetoxy)borohydride; acetic acid / 72 h / 20 °C

2: water; lithium hydroxide / tetrahydrofuran / 4 h / 20 °C

With water; sodium tris(acetoxy)borohydride; acetic acid; lithium hydroxide; In tetrahydrofuran;