2-(N-(5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)benzofuran-6-yl)methylsulfonamido)ethyl dihydrogen phosphate

Base Information

Chemical Name:2-(N-(5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)benzofuran-6-yl)methylsulfonamido)ethyl dihydrogen phosphate
CAS No.:1246280-88-5
Molecular Formula:C₂₂H₂₄FN₂O₈PS
Molecular Weight:526.479
Hs Code.:

Synonyms:2-(N-(5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)benzofuran-6-yl)methylsulfonamido)ethyl dihydrogen phosphate

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Chemical Property of 2-(N-(5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)benzofuran-6-yl)methylsulfonamido)ethyl dihydrogen phosphate

Chemical Property:

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Technology Process of 2-(N-(5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)benzofuran-6-yl)methylsulfonamido)ethyl dihydrogen phosphate

There total 2 articles about 2-(N-(5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)benzofuran-6-yl)methylsulfonamido)ethyl dihydrogen phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1246280-91-0
phosphoric acid ((2R,3S,4R,5R)-5-(3-carbamoyl-[1,2,4]-triazol-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-ylmethyl) ester 2-{[5-cyclopropyl-2-(4-fluorophenyl)-3-methylcarbamoylbenzofuran-6-yl]methanesulfonylamino}ethyl ester

: 691852-58-1
nesbuvir

: 1246280-88-5
2-(N-(5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)benzofuran-6-yl)methylsulfonamido)ethyl dihydrogen phosphate

: 36791-04-5,66510-90-5
ribavirin

Guidance literature:: With phospholipase D from Streptomyces chromofuscus; at 20 ℃; aq. buffer (TRIS/HCl, pH 9.2); Enzymatic reaction;
DOI:10.1016/j.bmcl.2010.06.156

Reference yield:

: 691852-58-1
nesbuvir

: 1246280-88-5
2-(N-(5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)benzofuran-6-yl)methylsulfonamido)ethyl dihydrogen phosphate

Guidance literature:: nesbuvir; With pyridine; trichlorophosphate; In tetrahydrofuran; dichloromethane; at -10 - -4 ℃; for 4h; Inert atmosphere;

With water; at 5 - 20 ℃;
DOI:10.1016/j.bmcl.2010.06.156