methyl (3aR,8aR)-tetrahydro-2,2-dimethyl-4,4,8,8-tetraphenyl-1,3-dioxolo[4,5-e][1,3,2]dioxaphosphepin-6-acetate 6-oxide

Base Information

Chemical Name:methyl (3aR,8aR)-tetrahydro-2,2-dimethyl-4,4,8,8-tetraphenyl-1,3-dioxolo[4,5-e][1,3,2]dioxaphosphepin-6-acetate 6-oxide
CAS No.:1399829-83-4
Molecular Formula:C₃₄H₃₃O₇P
Molecular Weight:584.606
Hs Code.:

Synonyms:methyl (3aR,8aR)-tetrahydro-2,2-dimethyl-4,4,8,8-tetraphenyl-1,3-dioxolo[4,5-e][1,3,2]dioxaphosphepin-6-acetate 6-oxide

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Chemical Property of methyl (3aR,8aR)-tetrahydro-2,2-dimethyl-4,4,8,8-tetraphenyl-1,3-dioxolo[4,5-e][1,3,2]dioxaphosphepin-6-acetate 6-oxide

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Technology Process of methyl (3aR,8aR)-tetrahydro-2,2-dimethyl-4,4,8,8-tetraphenyl-1,3-dioxolo[4,5-e][1,3,2]dioxaphosphepin-6-acetate 6-oxide

There total 2 articles about methyl (3aR,8aR)-tetrahydro-2,2-dimethyl-4,4,8,8-tetraphenyl-1,3-dioxolo[4,5-e][1,3,2]dioxaphosphepin-6-acetate 6-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 17640-15-2
methyl cyanoformate

: 1399829-81-2
(3aR,8aR)-tetrahydro-2,2,6-trimethyl-4,4,8,8-tetraphenyl-1,3-dioxolo[4,5-e][1,3,2]dioxaphosphepin 6-oxide

: 1399829-83-4
methyl (3aR,8aR)-tetrahydro-2,2-dimethyl-4,4,8,8-tetraphenyl-1,3-dioxolo[4,5-e][1,3,2]dioxaphosphepin-6-acetate 6-oxide

Guidance literature:: (3aR,8aR)-tetrahydro-2,2,6-trimethyl-4,4,8,8-tetraphenyl-1,3-dioxolo[4,5-e][1,3,2]dioxaphosphepin 6-oxide; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 3.5h;

methyl cyanoformate; In tetrahydrofuran; at -78 ℃; for 1h;
DOI:10.1002/hlca.201200147

Reference yield:

: 93379-48-7
(R,R)-TADDOL

: 1399829-83-4
methyl (3aR,8aR)-tetrahydro-2,2-dimethyl-4,4,8,8-tetraphenyl-1,3-dioxolo[4,5-e][1,3,2]dioxaphosphepin-6-acetate 6-oxide

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran / 1 h / -78 - 20 °C

1.2: 3.5 h / -78 - 20 °C

2.1: n-butyllithium / tetrahydrofuran / 3.5 h / -78 °C

2.2: 1 h / -78 °C

With n-butyllithium; In tetrahydrofuran;
DOI:10.1002/hlca.201200147