5-amino-2,3-di-O-benzyl-6-O-[(tert-butyl)dimethylsilyl]-5-deoxy-4-O-(methoxymethyl)-D-galactono-1,5-lactam

Base Information

Chemical Name:5-amino-2,3-di-O-benzyl-6-O-[(tert-butyl)dimethylsilyl]-5-deoxy-4-O-(methoxymethyl)-D-galactono-1,5-lactam
CAS No.:896448-00-3
Molecular Formula:C₂₈H₄₁NO₆Si
Molecular Weight:515.722
Hs Code.:

Synonyms:5-amino-2,3-di-O-benzyl-6-O-[(tert-butyl)dimethylsilyl]-5-deoxy-4-O-(methoxymethyl)-D-galactono-1,5-lactam

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Chemical Property of 5-amino-2,3-di-O-benzyl-6-O-[(tert-butyl)dimethylsilyl]-5-deoxy-4-O-(methoxymethyl)-D-galactono-1,5-lactam

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Technology Process of 5-amino-2,3-di-O-benzyl-6-O-[(tert-butyl)dimethylsilyl]-5-deoxy-4-O-(methoxymethyl)-D-galactono-1,5-lactam

There total 3 articles about 5-amino-2,3-di-O-benzyl-6-O-[(tert-butyl)dimethylsilyl]-5-deoxy-4-O-(methoxymethyl)-D-galactono-1,5-lactam which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 896447-97-5
5-amino-2,3-di-O-benzyl-6-O-[(tert-butyl)dimethylsilyl]-5-deoxy-D-galactono-1,5-lactam

: 107-30-2
chloromethyl methyl ether

: 896448-00-3
5-amino-2,3-di-O-benzyl-6-O-[(tert-butyl)dimethylsilyl]-5-deoxy-4-O-(methoxymethyl)-D-galactono-1,5-lactam

Guidance literature:: With N,N-diethyl-N-isopropylamine; tetra-(n-butyl)ammonium iodide; 4-pyrrolidin-1-ylpyridine; In 1,2-dichloro-ethane; at 80 ℃; for 16h;
DOI:10.1002/hlca.200690066

Reference yield:

: 896447-96-4
5-amino-2,3-di-O-benzyl-5-deoxy-D-galactono-1,5-lactam

: 896448-00-3
5-amino-2,3-di-O-benzyl-6-O-[(tert-butyl)dimethylsilyl]-5-deoxy-4-O-(methoxymethyl)-D-galactono-1,5-lactam

Guidance literature:: Multi-step reaction with 2 steps

1: 87 percent / Et₃N; DMAP / dimethylformamide / 16 h / 23 °C

2: 85 percent / (i-Pr)NEt₂; Bu₄NI; 4-pyrrolidinopyridine / 1,2-dichloro-ethane / 16 h / 80 °C

With dmap; N,N-diethyl-N-isopropylamine; tetra-(n-butyl)ammonium iodide; 4-pyrrolidin-1-ylpyridine; triethylamine; In 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1002/hlca.200690066

Reference yield:

: 916494-99-0
5-amino-2,3-di-O-benzyl-4,6-O-benzylidene-5-deoxy-D-galactono-1,5-lactam

: 896448-00-3
5-amino-2,3-di-O-benzyl-6-O-[(tert-butyl)dimethylsilyl]-5-deoxy-4-O-(methoxymethyl)-D-galactono-1,5-lactam

Guidance literature:: Multi-step reaction with 3 steps

1: 75 percent / CF₃COOH / CH₂Cl₂; H₂O / 24 h / 23 °C

2: 87 percent / Et₃N; DMAP / dimethylformamide / 16 h / 23 °C

3: 85 percent / (i-Pr)NEt₂; Bu₄NI; 4-pyrrolidinopyridine / 1,2-dichloro-ethane / 16 h / 80 °C

With dmap; N,N-diethyl-N-isopropylamine; tetra-(n-butyl)ammonium iodide; 4-pyrrolidin-1-ylpyridine; triethylamine; trifluoroacetic acid; In dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1002/hlca.200690066