(1S,4R,5R)-4-(tert-Butyl-dimethyl-silanyloxymethyl)-5-isopropyl-2-methyl-cyclohex-2-enol

Base Information

Chemical Name:(1S,4R,5R)-4-(tert-Butyl-dimethyl-silanyloxymethyl)-5-isopropyl-2-methyl-cyclohex-2-enol
CAS No.:198335-98-7
Molecular Formula:C₁₇H₃₄O₂Si
Molecular Weight:298.541
Hs Code.:

Synonyms:(1S,4R,5R)-4-(tert-Butyl-dimethyl-silanyloxymethyl)-5-isopropyl-2-methyl-cyclohex-2-enol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1S,4R,5R)-4-(tert-Butyl-dimethyl-silanyloxymethyl)-5-isopropyl-2-methyl-cyclohex-2-enol

Chemical Property:

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Technology Process of (1S,4R,5R)-4-(tert-Butyl-dimethyl-silanyloxymethyl)-5-isopropyl-2-methyl-cyclohex-2-enol

There total 7 articles about (1S,4R,5R)-4-(tert-Butyl-dimethyl-silanyloxymethyl)-5-isopropyl-2-methyl-cyclohex-2-enol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 223790-28-1
Methanesulfonic acid (1S,2R,3S,4R,6S)-3-(tert-butyl-dimethyl-silanyloxymethyl)-4-isopropyl-1-methyl-7-oxa-bicyclo[4.1.0]hept-2-yl ester

: 198335-98-7
(1S,4R,5R)-4-(tert-Butyl-dimethyl-silanyloxymethyl)-5-isopropyl-2-methyl-cyclohex-2-enol

Guidance literature:: With sodium naphthalenide; In tetrahydrofuran; at 0 ℃; for 0.5h; Yield given;
DOI:10.1021/ja981062g

Reference yield:

: 2244-16-8,6485-40-1
(S)-p-mentha-6,8-dien-2-one

: 198335-98-7
(1S,4R,5R)-4-(tert-Butyl-dimethyl-silanyloxymethyl)-5-isopropyl-2-methyl-cyclohex-2-enol

Guidance literature:: Multi-step reaction with 7 steps

1: H₂O₂, NaOH / methanol / 2 h / 0 °C

2: H₂ / PtO₂ / ethanol / 12 h / 25 °C

3: 1.) LDA / 2.) THF, from -78 to 0 deg C, 2 h

4: Et₃N / CH₂Cl₂ / 12 h

5: 93 percent / L-selectride / tetrahydrofuran / 2 h / -78 °C

6: Et₃N / CH₂Cl₂ / 0.5 h / 0 °C

7: sodium naphthalenide / tetrahydrofuran / 0.5 h / 0 °C

With sodium hydroxide; hydrogen; dihydrogen peroxide; L-Selectride; sodium naphthalenide; triethylamine; lithium diisopropyl amide; platinum(IV) oxide; In tetrahydrofuran; methanol; ethanol; dichloromethane;
DOI:10.1021/ja981062g

Reference yield:

: 39903-97-4
(S)-carvone oxide

: 198335-98-7
(1S,4R,5R)-4-(tert-Butyl-dimethyl-silanyloxymethyl)-5-isopropyl-2-methyl-cyclohex-2-enol

Guidance literature:: Multi-step reaction with 6 steps

1: H₂ / PtO₂ / ethanol / 12 h / 25 °C

2: 1.) LDA / 2.) THF, from -78 to 0 deg C, 2 h

3: Et₃N / CH₂Cl₂ / 12 h

4: 93 percent / L-selectride / tetrahydrofuran / 2 h / -78 °C

5: Et₃N / CH₂Cl₂ / 0.5 h / 0 °C

6: sodium naphthalenide / tetrahydrofuran / 0.5 h / 0 °C

With hydrogen; L-Selectride; sodium naphthalenide; triethylamine; lithium diisopropyl amide; platinum(IV) oxide; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/ja981062g