N',N''-bis(6-(tert-butoxycarbonyl)aminohexyl)-N^α-benzyloxycarbonyl-L-glutamide

Base Information

Chemical Name:N',N''-bis(6-(tert-butoxycarbonyl)aminohexyl)-N^α-benzyloxycarbonyl-L-glutamide
CAS No.:862157-10-6
Molecular Formula:C₃₅H₅₉N₅O₈
Molecular Weight:677.882
Hs Code.:

N',N''-bis(6-(tert-butoxycarbonyl)aminohexyl)-N<sup>α</sup>-benzyloxycarbonyl-L-glutamide

Synonyms:N',N''-bis(6-(tert-butoxycarbonyl)aminohexyl)-N^α-benzyloxycarbonyl-L-glutamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N',N''-bis(6-(tert-butoxycarbonyl)aminohexyl)-N^α-benzyloxycarbonyl-L-glutamide

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Technology Process of N',N''-bis(6-(tert-butoxycarbonyl)aminohexyl)-N^α-benzyloxycarbonyl-L-glutamide

There total 1 articles about N',N''-bis(6-(tert-butoxycarbonyl)aminohexyl)-N^α-benzyloxycarbonyl-L-glutamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 51857-17-1
tert-butyl N-(6-aminohexyl)carbamate

: 49761-26-4
N-benzyloxycarbonyl-L-glutamic acid bis(4-nitrophenyl)ester

: 862157-10-6
N',N''-bis(6-(tert-butoxycarbonyl)aminohexyl)-N^α-benzyloxycarbonyl-L-glutamide

Guidance literature:: With triethylamine; In ethyl acetate; at 20 ℃; for 48h;
DOI:10.1039/b505700k

Reference yield:

: 862157-10-6
N',N''-bis(6-(tert-butoxycarbonyl)aminohexyl)-N^α-benzyloxycarbonyl-L-glutamide

: [(S)-1,3-Bis-(6-amino-hexylcarbamoyl)-propyl]-carbamic acid benzyl ester

Guidance literature:: With trifluoroacetic acid; at 20 ℃; for 1h;
DOI:10.1039/b505700k

Reference yield:

: 862157-10-6
N',N''-bis(6-(tert-butoxycarbonyl)aminohexyl)-N^α-benzyloxycarbonyl-L-glutamide

: 862157-11-7
((S)-1,3-Bis-{6-[5-(9,9-dimethyl-3,7-dioxo-2,4,6,8-tetraaza-bicyclo[3.3.1]non-1-yl)-pentanoylamino]-hexylcarbamoyl}-propyl)-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: TFA / 1 h / 20 °C

2: 387 mg / diphenylphosphoryl azide; Et₃N / dimethylsulfoxide / 24 h / 20 °C

With diphenylphosphoranyl azide; triethylamine; trifluoroacetic acid; In dimethyl sulfoxide;
DOI:10.1039/b505700k