4-amino-N-(3,5-dimethoxyphenyl)thieno[3,2-d]pyrimidine-7-carboxamide

Base Information

Chemical Name:4-amino-N-(3,5-dimethoxyphenyl)thieno[3,2-d]pyrimidine-7-carboxamide
CAS No.:1318128-91-4
Molecular Formula:C₁₅H₁₄N₄O₃S
Molecular Weight:330.367
Hs Code.:

Synonyms:4-amino-N-(3,5-dimethoxyphenyl)thieno[3,2-d]pyrimidine-7-carboxamide

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Chemical Property of 4-amino-N-(3,5-dimethoxyphenyl)thieno[3,2-d]pyrimidine-7-carboxamide

Chemical Property:

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Technology Process of 4-amino-N-(3,5-dimethoxyphenyl)thieno[3,2-d]pyrimidine-7-carboxamide

There total 9 articles about 4-amino-N-(3,5-dimethoxyphenyl)thieno[3,2-d]pyrimidine-7-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1318132-98-7
N-(3,5-dimethoxyphenyl)-4-(methylsulfinyl)thieno[3,2-d]pyrimidine-7-carboxamide

: 1318128-91-4
4-amino-N-(3,5-dimethoxyphenyl)thieno[3,2-d]pyrimidine-7-carboxamide

Guidance literature:: With ammonia; In isopropyl alcohol; at 110 ℃; for 15h; closed vessel;

Reference yield:

: 16234-10-9
3H-thieno[3,2-d]pyrimidin-4-one

: 1318128-91-4
4-amino-N-(3,5-dimethoxyphenyl)thieno[3,2-d]pyrimidine-7-carboxamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: bromine / acetic acid / 10 h / 120 °C / closed reactor

2.1: trichlorophosphate / 3 h / 150 °C

3.1: tetrahydrofuran / 15 h / 0 °C

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 2.5 h / 120 °C

4.2: 1 h / 20 °C

5.1: ozone / chloroform; methanol / 0.5 h / -78 °C

6.1: sodium chlorite; sodium dihydrogenphosphate dihydrate / water; dimethyl sulfoxide; acetone / 0 - 20 °C

7.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / acetonitrile / 15 h / 20 °C

8.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 3 h / 0 °C

9.1: ammonia / isopropyl alcohol / 15 h / 110 °C / closed vessel

With sodium chlorite; sodium dihydrogenphosphate dihydrate; ammonia; bromine; benzotriazol-1-ol; ozone; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-chloro-benzenecarboperoxoic acid; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; chloroform; water; acetic acid; dimethyl sulfoxide; isopropyl alcohol; acetone; acetonitrile;

Reference yield:

: 31169-27-4
7-bromo-4-chlorothieno[3,2-d]pyrimidine

: 1318128-91-4
4-amino-N-(3,5-dimethoxyphenyl)thieno[3,2-d]pyrimidine-7-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: tetrahydrofuran / 15 h / 0 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 2.5 h / 120 °C

2.2: 1 h / 20 °C

3.1: ozone / chloroform; methanol / 0.5 h / -78 °C

4.1: sodium chlorite; sodium dihydrogenphosphate dihydrate / water; dimethyl sulfoxide; acetone / 0 - 20 °C

5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / acetonitrile / 15 h / 20 °C

6.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 3 h / 0 °C

7.1: ammonia / isopropyl alcohol / 15 h / 110 °C / closed vessel

With sodium chlorite; sodium dihydrogenphosphate dihydrate; ammonia; benzotriazol-1-ol; ozone; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-chloro-benzenecarboperoxoic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; chloroform; water; dimethyl sulfoxide; isopropyl alcohol; acetone; acetonitrile;