Phthalimidine, 2-acetyl-3-methyl- (2CI)

Base Information

• Chemical Name: Phthalimidine, 2-acetyl-3-methyl- (2CI)
• CAS No.: 861589-64-2
• Molecular Formula: C₁₁H₁₁NO₂
• Molecular Weight: 189.214
• Mol file: 861589-64-2.mol

Synonyms:Phthalimidine,2-acetyl-3-methyl- (2CI)

Chemical Property of Phthalimidine, 2-acetyl-3-methyl- (2CI)

Chemical Property:

• Boiling Point: 325.7±35.0 °C(Predicted)
• PKA: -2.03±0.40(Predicted)
• PSA: 37.38000
• Density: 1.202±0.06 g/cm3(Predicted)
• LogP: 1.68780

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Phthalimidine, 2-acetyl-3-methyl- (2CI)

There total 3 articles about Phthalimidine, 2-acetyl-3-methyl- (2CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

acetonitrile (75-05-8,26809-02-9) + 2-ethylbenzoic acid (612-19-1) → 2-acetyl-3-methylisoindolin-1-one (861589-64-2)

Guidance literature:

With tris(2,4-pentanedionato)iron(III); copper(II) nitrate; 1-(chloromethyl)-4-fluoro-1,4-diazoniabicyclo-[2.2.2]octane bis(tetrafluoroborate); at 80 ℃; for 8h; Schlenk technique; Inert atmosphere;

DOI:10.1002/chem.201600107

Reference yield:

1-bromo-2-ethylbenzene (1973-22-4) → 2-acetyl-3-methylisoindolin-1-one (861589-64-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere

1.2: 1.33 h / -78 - 20 °C / Inert atmosphere

2.1: tetra-n-butylammonium tetrafluoroborate; benzoic acid / 2,2,2-trifluoroethanol / 4 h / 40 °C / Inert atmosphere; Electrolysis

With tetra-n-butylammonium tetrafluoroborate; benzoic acid; In tetrahydrofuran; hexane; 2,2,2-trifluoroethanol;

DOI:10.1039/d1gc04676d

Reference yield:

acetic anhydride (108-24-7) → 2-acetyl-3-methylisoindolin-1-one (861589-64-2)

Guidance literature:

With potassium acetate;

upstream raw materials:

acetic anhydride

acetonitrile

2-ethylbenzoic acid

1-bromo-2-ethylbenzene