meso-dimethyl 2,3-dihydroxy-2,3-diphenylsuccinate

Base Information

• Chemical Name: meso-dimethyl 2,3-dihydroxy-2,3-diphenylsuccinate
• CAS No.: 74956-42-6
• Molecular Formula: C₁₈H₁₈O₆
• Molecular Weight: 330.337
• Mol file: 74956-42-6.mol

Synonyms:meso-dimethyl 2,3-dihydroxy-2,3-diphenylsuccinate

Chemical Property of meso-dimethyl 2,3-dihydroxy-2,3-diphenylsuccinate

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of meso-dimethyl 2,3-dihydroxy-2,3-diphenylsuccinate

There total 50 articles about meso-dimethyl 2,3-dihydroxy-2,3-diphenylsuccinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

methyl 2-oxo-2-phenylacetate (15206-55-0) + 4-methyl-benzaldehyde (104-87-0) + aniline (62-53-3) → (RS)-methyl mandelate (4358-87-6) + meso-dimethyl 2,3-dihydroxy-2,3-diphenylsuccinate (74956-42-6) + (2S,3R)-2-Hydroxy-2-phenyl-3-phenylamino-3-p-tolyl-propionic acid methyl ester

Guidance literature:

With pyridine; titanium(III) chloride; In tetrahydrofuran; dichloromethane; for 0.5h; Yields of byproduct given; Ambient temperature;

DOI:10.1016/00404-0399(50)11517-

Reference yield: 64.0%

methyl 2-oxo-2-phenylacetate (15206-55-0) + aniline (62-53-3) + ortho-anisaldehyde (135-02-4) → (RS)-methyl mandelate (4358-87-6) + meso-dimethyl 2,3-dihydroxy-2,3-diphenylsuccinate (74956-42-6) + (2S,3R)-2-Hydroxy-3-(2-methoxy-phenyl)-2-phenyl-3-phenylamino-propionic acid methyl ester

Guidance literature:

With pyridine; titanium(III) chloride; In tetrahydrofuran; dichloromethane; for 0.5h; Yields of byproduct given; Ambient temperature;

DOI:10.1016/00404-0399(50)11517-

Reference yield: 63.0%

methyl 2-oxo-2-phenylacetate (15206-55-0) + aniline (62-53-3) + 4-cyanobenzaldehyde (105-07-7) → (RS)-methyl mandelate (4358-87-6) + meso-dimethyl 2,3-dihydroxy-2,3-diphenylsuccinate (74956-42-6) + (2S,3R)-3-(4-Cyano-phenyl)-2-hydroxy-2-phenyl-3-phenylamino-propionic acid methyl ester

Guidance literature:

With pyridine; titanium(III) chloride; In tetrahydrofuran; dichloromethane; for 0.5h; Yields of byproduct given; Ambient temperature;

DOI:10.1016/00404-0399(50)11517-

upstream raw materials:

methyl 2-oxo-2-phenylacetate

dimethyl 2,3-dihydroxy-2,3-diphenylbutanedioate

4-bromo-benzaldehyde

(RS)-methyl mandelate

Downstream raw materials:

methyl 2-oxo-2-phenylacetate

(RS)-methyl mandelate

dimethyl 2,3-dihydroxy-2,3-diphenylbutanedioate

methyl 2-phenyl-2,3-dihydroxy-3-methylbutanoate