11β-{4-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]phenyl}-20,20,21,21,21-pentafluoro-5,17-dihydroxy-19-nor-5α,17α-pregn-9-en-3-one 2,2-dimethylpropane-1,3-diyl ketal

Base Information

• Chemical Name: 11β-{4-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]phenyl}-20,20,21,21,21-pentafluoro-5,17-dihydroxy-19-nor-5α,17α-pregn-9-en-3-one 2,2-dimethylpropane-1,3-diyl ketal
• CAS No.: 1026668-62-1
• Molecular Formula: C₃₆H₄₇F₅O₆
• Molecular Weight: 670.758

Synonyms:11β-{4-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]phenyl}-20,20,21,21,21-pentafluoro-5,17-dihydroxy-19-nor-5α,17α-pregn-9-en-3-one 2,2-dimethylpropane-1,3-diyl ketal

Chemical Property of 11β-{4-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]phenyl}-20,20,21,21,21-pentafluoro-5,17-dihydroxy-19-nor-5α,17α-pregn-9-en-3-one 2,2-dimethylpropane-1,3-diyl ketal

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Technology Process of 11β-{4-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]phenyl}-20,20,21,21,21-pentafluoro-5,17-dihydroxy-19-nor-5α,17α-pregn-9-en-3-one 2,2-dimethylpropane-1,3-diyl ketal

There total 1 articles about 11β-{4-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]phenyl}-20,20,21,21,21-pentafluoro-5,17-dihydroxy-19-nor-5α,17α-pregn-9-en-3-one 2,2-dimethylpropane-1,3-diyl ketal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

(R)-4-(4-bromophenyl)-2,2-dimethyl-1,3-dioxolane (1026668-60-9) + (5′R,8′S,10′R,13′S,14′S,17′S)-5,5,13′-trimethyl-17′-(pentafluoroethyl)-1′,2′,7′,8′,12′,13′,14′,15′,16′,17′-decahydro-6′H-spiro[1,3-dioxane-2,3′-[5,10]epoxycyclopenta[a]phenanthren]-17′-ol (1026668-61-0) → 11β-{4-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]phenyl}-20,20,21,21,21-pentafluoro-5,17-dihydroxy-19-nor-5α,17α-pregn-9-en-3-one 2,2-dimethylpropane-1,3-diyl ketal (1026668-62-1)

Guidance literature:

With magnesium; copper(l) chloride; In tetrahydrofuran; at 0 - 65 ℃; for 2h;

Reference yield: 61.2%

11β-{4-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]phenyl}-20,20,21,21,21-pentafluoro-5,17-dihydroxy-19-nor-5α,17α-pregn-9-en-3-one 2,2-dimethylpropane-1,3-diyl ketal (1026668-62-1) → 11β-[4-[(1R)-1,2-dihydroxyethyl]phenyl]-20,20,21,21,21-pentafluoro-17-hydroxy-19-nor-17α-pregna-4,9-dien-3-one (1026668-54-1)

Guidance literature:

With sulfuric acid; In tetrahydrofuran; water; at 20 ℃; for 3h; Product distribution / selectivity;

upstream raw materials:

(R)-4-(4-bromophenyl)-2,2-dimethyl-1,3-dioxolane

(5′R,8′S,10′R,13′S,14′S,17′S)-5,5,13′-trimethyl-17′-(pentafluoroethyl)-1′,2′,7′,8′,12′,13′,14′,15′,16′,17′-decahydro-6′H-spiro[1,3-dioxane-2,3′-[5,10]epoxycyclopenta[a]phenanthren]-17′-ol

Downstream raw materials:

11β-[4-[(1R)-1,2-dihydroxyethyl]phenyl]-20,20,21,21,21-pentafluoro-17-hydroxy-19-nor-17α-pregna-4,9-dien-3-one

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