tert-butyl 4-(((3-((2-(3-Fluoro-4-(methylsulfonamido)phenyl)propanamido)methyl)-6-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-(((3-((2-(3-Fluoro-4-(methylsulfonamido)phenyl)propanamido)methyl)-6-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidine-1-carboxylate
CAS No.:1348424-00-9
Molecular Formula:C₂₈H₃₇F₄N₅O₅S
Molecular Weight:631.692
Hs Code.:

tert-butyl 4-(((3-((2-(3-Fluoro-4-(methylsulfonamido)phenyl)propanamido)methyl)-6-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidine-1-carboxylate

Synonyms:tert-butyl 4-(((3-((2-(3-Fluoro-4-(methylsulfonamido)phenyl)propanamido)methyl)-6-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-(((3-((2-(3-Fluoro-4-(methylsulfonamido)phenyl)propanamido)methyl)-6-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidine-1-carboxylate

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Technology Process of tert-butyl 4-(((3-((2-(3-Fluoro-4-(methylsulfonamido)phenyl)propanamido)methyl)-6-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidine-1-carboxylate

There total 4 articles about tert-butyl 4-(((3-((2-(3-Fluoro-4-(methylsulfonamido)phenyl)propanamido)methyl)-6-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 824426-35-9
2-[3-fluoro-4-(methylsulfonylamino)phenyl]propionic acid

: 935518-58-4
4-[(3-aminomethyl-6-trifluoromethyl-pyridin-2-ylamino)-methyl]-piperidine-1-carbonic acid tert-butyl ester

: 1348424-00-9
tert-butyl 4-(((3-((2-(3-Fluoro-4-(methylsulfonamido)phenyl)propanamido)methyl)-6-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidine-1-carboxylate

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 12h;
DOI:10.1021/jm300780p

Reference yield:

: 935517-58-1
4-[(3-cyano-6-trifluoromethyl-pyridin-2-ylamino)-methyl]-piperidine-1-carbonic acid tert-butyl ester

: 1348424-00-9
tert-butyl 4-(((3-((2-(3-Fluoro-4-(methylsulfonamido)phenyl)propanamido)methyl)-6-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tetrahydroborate; nickel(II) chloride hexahydrate / methanol / 12 h / Reflux

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 12 h / 20 °C

With sodium tetrahydroborate; nickel(II) chloride hexahydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm300780p

Reference yield:

: 116548-04-0
2-oxo-6-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile

: 1348424-00-9
tert-butyl 4-(((3-((2-(3-Fluoro-4-(methylsulfonamido)phenyl)propanamido)methyl)-6-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: trichlorophosphate / 3 h / Reflux

2: 16 h / 20 °C

3: sodium tetrahydroborate; nickel(II) chloride hexahydrate / methanol / 12 h / Reflux

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 12 h / 20 °C

With sodium tetrahydroborate; nickel(II) chloride hexahydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trichlorophosphate; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm300780p