(S)-N-allyl-2-amino-3-phenylpropanamide

Base Information

• Chemical Name: (S)-N-allyl-2-amino-3-phenylpropanamide
• CAS No.: 160555-66-8
• Molecular Formula: C₁₂H₁₆N₂O
• Molecular Weight: 204.272
• Mol file: 160555-66-8.mol

Synonyms:(S)-N-allyl-2-amino-3-phenylpropanamide

Chemical Property of (S)-N-allyl-2-amino-3-phenylpropanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-N-allyl-2-amino-3-phenylpropanamide

There total 4 articles about (S)-N-allyl-2-amino-3-phenylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

methyl (2S)-2-amino-3-phenylpropanoate hydrochloride (7524-50-7) + 1-amino-2-propene (107-11-9,30551-89-4) → (S)-N-allyl-2-amino-3-phenylpropanamide (160555-66-8)

Guidance literature:

at 60 ℃; for 72h; Schlenk technique; Inert atmosphere; Sealed tube;

DOI:10.1039/d1cc04154a

Reference yield: 92.0%

(S)-tert-butyl (1-(allylamino)-1-oxo-3-phenylpropan-2-yl)carbamate (120125-16-8) → (S)-N-allyl-2-amino-3-phenylpropanamide (160555-66-8)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃;

DOI:10.1002/anie.202109344

Reference yield:

L-phenylalanine (63-91-2,25191-15-5,658-69-5,67675-33-6) → (S)-N-allyl-2-amino-3-phenylpropanamide (160555-66-8)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydroxide / water; 1,4-dioxane / 12 h / 20 °C

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 12 h / 0 - 20 °C

3: trifluoroacetic acid / dichloromethane / 20 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; sodium hydroxide; In 1,4-dioxane; dichloromethane; water;

DOI:10.1002/anie.202109344

upstream raw materials:

methyl (2S)-2-amino-3-phenylpropanoate hydrochloride

1-amino-2-propene

L-phenylalanine

N-tert-butoxycarbonyl-L-phenylalanine