N-(2-(tert-butoxycarbonylamino)phenyl)-4-(3-cyano-5-formylpyridin-2-yl)benzamide

Base Information

• Chemical Name: N-(2-(tert-butoxycarbonylamino)phenyl)-4-(3-cyano-5-formylpyridin-2-yl)benzamide
• CAS No.: 1030927-09-3
• Molecular Formula: C₂₅H₂₂N₄O₄
• Molecular Weight: 442.474
• Mol file: 1030927-09-3.mol

Synonyms:N-(2-(tert-butoxycarbonylamino)phenyl)-4-(3-cyano-5-formylpyridin-2-yl)benzamide

Chemical Property of N-(2-(tert-butoxycarbonylamino)phenyl)-4-(3-cyano-5-formylpyridin-2-yl)benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-(tert-butoxycarbonylamino)phenyl)-4-(3-cyano-5-formylpyridin-2-yl)benzamide

There total 1 articles about N-(2-(tert-butoxycarbonylamino)phenyl)-4-(3-cyano-5-formylpyridin-2-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

2-chloro-3-cyano-5-formylpyridine (176433-46-8) + N-(2-(tert-butoxycarbonylamino)phenyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide (617703-01-2) → N-(2-(tert-butoxycarbonylamino)phenyl)-4-(3-cyano-5-formylpyridin-2-yl)benzamide (1030927-09-3)

Guidance literature:

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium hydrogencarbonate; In 1,2-dimethoxyethane; water; at 60 ℃; for 7.5h; Inert atmosphere;

DOI:10.1021/op300021m

Reference yield: 97.0%

N-(2-(tert-butoxycarbonylamino)phenyl)-4-(3-cyano-5-formylpyridin-2-yl)benzamide (1030927-09-3) → t-butyl[2-({4-[3-cyano-5-(hydroxymethyl)pyridin-2-yl]benzoyl}amino)phenyl]carbamate

Guidance literature:

With sodium tetrahydroborate; In methanol; at 20 ℃; for 1h;

Reference yield: 57.0%

N-(2-(tert-butoxycarbonylamino)phenyl)-4-(3-cyano-5-formylpyridin-2-yl)benzamide (1030927-09-3) + methoxyisopropylamine (37143-54-7) → N-(2-aminophenyl)-4-(3-cyano-5-{[(2-methoxy-1-methylethyl)amino]methyl}pyridin-2-yl)benzamide

Guidance literature:

N-(2-(tert-butoxycarbonylamino)phenyl)-4-(3-cyano-5-formylpyridin-2-yl)benzamide; methoxyisopropylamine; With titanium(IV)isopropoxide; In dichloromethane; at 20 ℃; for 2h;

With sodium tetrahydroborate; In methanol; dichloromethane; for 2h;

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 4h;

upstream raw materials:

2-chloro-3-cyano-5-formylpyridine

N-(2-(tert-butoxycarbonylamino)phenyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide

Downstream raw materials:

tert-butyl [2-({4-[3-cyano-5-(morpholin-4-ylmethyl)pyridin-2-yl]benzoyl}amino)phenyl]carbamate

N-(2-aminophenyl)-4-[3-cyano-5-[(4-isopropylpiperazin-1-yl)methyl]-2-pyridyl]benzamide

C₂₄H₂₃N₅O₂

tert-butyl [2-({4-[5-(chloromethyl)-3-cyanopyridin-2-yl]benzoyl}amino)phenyl]carbamate