1,2-anhydro-2-C-ethynyl-3,5-bis(2,4-dichlorobenzyloxymethyl)-α-D-ribofuranose

Base Information

Chemical Name:1,2-anhydro-2-C-ethynyl-3,5-bis(2,4-dichlorobenzyloxymethyl)-α-D-ribofuranose
CAS No.:1207518-56-6
Molecular Formula:C₂₁H₁₆Cl₄O₄
Molecular Weight:474.168
Hs Code.:

Synonyms:1,2-anhydro-2-C-ethynyl-3,5-bis(2,4-dichlorobenzyloxymethyl)-α-D-ribofuranose

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Chemical Property of 1,2-anhydro-2-C-ethynyl-3,5-bis(2,4-dichlorobenzyloxymethyl)-α-D-ribofuranose

Chemical Property:

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Technology Process of 1,2-anhydro-2-C-ethynyl-3,5-bis(2,4-dichlorobenzyloxymethyl)-α-D-ribofuranose

There total 2 articles about 1,2-anhydro-2-C-ethynyl-3,5-bis(2,4-dichlorobenzyloxymethyl)-α-D-ribofuranose which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (3R,4R,5R)-4-((2,4-dichlorobenzyl)oxy)-5-(((2,4-dichlorobenzyl)oxy)methyl)-3-ethynyltetrahydrofuran-2,3-diol

: 1207518-56-6
1,2-anhydro-2-C-ethynyl-3,5-bis(2,4-dichlorobenzyloxymethyl)-α-D-ribofuranose

Guidance literature:: With triethylamine; p-toluenesulfonyl chloride; dmap; In dichloromethane; at 20 ℃; for 1h; Product distribution / selectivity; Inert atmosphere;

Reference yield:

: 1044589-93-6
(3R,4R,5R)-5-(2,4-dichlorobenzyloxymethyl)-4-(2,4-dichlorobenzyloxy)-3-ethynyl-2-methoxy-tetrahydrofuran-3-ol

: 1207518-56-6
1,2-anhydro-2-C-ethynyl-3,5-bis(2,4-dichlorobenzyloxymethyl)-α-D-ribofuranose

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid; water / 50 °C

2: dmap; triethylamine; p-toluenesulfonyl chloride / dichloromethane

With dmap; water; triethylamine; p-toluenesulfonyl chloride; trifluoroacetic acid; In dichloromethane;

Reference yield:

: 741686-49-7
2-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)isoindoline-1,3-dione

: 1207518-56-6
1,2-anhydro-2-C-ethynyl-3,5-bis(2,4-dichlorobenzyloxymethyl)-α-D-ribofuranose

: 1207518-57-7
(2R,3R,4R,5R)-2-(4-(isoindole-1,3-dione-2-yl)-pyrrolo[2,3-d]pyrimidin-7-yl)-5-(2,4-dichlorobenzyloxymethyl)-4-(2,4-dichlorobenzyloxy)-3-ethynyl-tetrahydrofuran-3-ol

Guidance literature:: 2-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)isoindoline-1,3-dione; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 - 25 ℃; Inert atmosphere;

1,2-anhydro-2-C-ethynyl-3,5-bis(2,4-dichlorobenzyloxymethyl)-α-D-ribofuranose; In N,N-dimethyl-formamide; toluene; mineral oil; at 20 - 60 ℃; Inert atmosphere;

With citric acid; In water; N,N-dimethyl-formamide; toluene; mineral oil; for 0.25h;