9-[2-deoxy-3,5-di-O-(4-methylbenzoyl)-β-D-erythro-pentofuranosyl]-6-phenylpurine

Base Information

• Chemical Name: 9-[2-deoxy-3,5-di-O-(4-methylbenzoyl)-β-D-erythro-pentofuranosyl]-6-phenylpurine
• CAS No.: 328378-37-6
• Molecular Formula: C₃₂H₂₈N₄O₅
• Molecular Weight: 548.598
• Mol file: 328378-37-6.mol

Synonyms:9-[2-deoxy-3,5-di-O-(4-methylbenzoyl)-β-D-erythro-pentofuranosyl]-6-phenylpurine

Chemical Property of 9-[2-deoxy-3,5-di-O-(4-methylbenzoyl)-β-D-erythro-pentofuranosyl]-6-phenylpurine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 9-[2-deoxy-3,5-di-O-(4-methylbenzoyl)-β-D-erythro-pentofuranosyl]-6-phenylpurine

There total 6 articles about 9-[2-deoxy-3,5-di-O-(4-methylbenzoyl)-β-D-erythro-pentofuranosyl]-6-phenylpurine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

6-Chloro-9-(2-deoxy-3,5-di-O-p-toluoyl-β-D-erythro-pentofuranosyl)purine (91713-46-1) + phenylboronic acid (98-80-6) → 9-[2-deoxy-3,5-di-O-(4-methylbenzoyl)-β-D-erythro-pentofuranosyl]-6-phenylpurine (328378-37-6)

Guidance literature:

With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In toluene; at 100 ℃; under 8 Torr;

DOI:10.1135/cccc20001683

Reference yield: 68.0%

9-[2-deoxy-3,5-di-O-(4-methylbenzoyl)-β-D-erythro-pentofuranosyl]-6-(imidazol-1-yl)purine + phenylboronic acid (98-80-6) → 9-[2-deoxy-3,5-di-O-(4-methylbenzoyl)-β-D-erythro-pentofuranosyl]-6-phenylpurine (328378-37-6)

Guidance literature:

With potassium phosphate; imidazolium carbene derivative HCl salt; bis(1,5-cyclooctadiene)nickel ⁽⁰⁾; In tetrahydrofuran; at 60 ℃; for 8h;

DOI:10.1021/ol048490d

Reference yield:

6-phenyl-9H-purine (6505-01-7) + 2-deoxy-3,5-di-O-p-toluoyl-α-D-erythro-pentofuranosyl chloride (4330-21-6) → 9-[2-deoxy-3,5-di-O-(4-methylbenzoyl)-β-D-erythro-pentofuranosyl]-6-phenylpurine (328378-37-6) + C32H28N4O5

Guidance literature:

With sodium hydride; In acetonitrile; at 70 ℃; for 0.5h; Title compound not separated from byproducts;

DOI:10.1135/cccc20001683

upstream raw materials:

6-phenyl-9H-purine

2-deoxy-3,5-di-O-p-toluoyl-α-D-erythro-pentofuranosyl chloride

6-Chloro-9-(2-deoxy-3,5-di-O-p-toluoyl-β-D-erythro-pentofuranosyl)purine

phenylboronic acid