2-(4-ethynyl-2-fluorophenylamino)-N-(2-hydroxyethoxy)-1-methyl-6-oxo-1,4,5,6-tetrahydrocyclopenta[b]pyrrole-3-carboxamide

Base Information

Chemical Name:2-(4-ethynyl-2-fluorophenylamino)-N-(2-hydroxyethoxy)-1-methyl-6-oxo-1,4,5,6-tetrahydrocyclopenta[b]pyrrole-3-carboxamide
CAS No.:1088714-18-4
Molecular Formula:C₁₉H₁₈FN₃O₄
Molecular Weight:371.368
Hs Code.:

Synonyms:2-(4-ethynyl-2-fluorophenylamino)-N-(2-hydroxyethoxy)-1-methyl-6-oxo-1,4,5,6-tetrahydrocyclopenta[b]pyrrole-3-carboxamide

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Chemical Property of 2-(4-ethynyl-2-fluorophenylamino)-N-(2-hydroxyethoxy)-1-methyl-6-oxo-1,4,5,6-tetrahydrocyclopenta[b]pyrrole-3-carboxamide

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Technology Process of 2-(4-ethynyl-2-fluorophenylamino)-N-(2-hydroxyethoxy)-1-methyl-6-oxo-1,4,5,6-tetrahydrocyclopenta[b]pyrrole-3-carboxamide

There total 7 articles about 2-(4-ethynyl-2-fluorophenylamino)-N-(2-hydroxyethoxy)-1-methyl-6-oxo-1,4,5,6-tetrahydrocyclopenta[b]pyrrole-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₂H₂₆FN₃O₄Si

: 1088714-18-4
2-(4-ethynyl-2-fluorophenylamino)-N-(2-hydroxyethoxy)-1-methyl-6-oxo-1,4,5,6-tetrahydrocyclopenta[b]pyrrole-3-carboxamide

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran;
DOI:10.1016/j.bmcl.2012.02.026

Reference yield:

: 1088714-16-2
2-(2-fluoro-4-iodophenylamino)-N-(2-hydroxyethoxy)-1-methyl-6-oxo-1,4,5,6-tetrahydrocyclopenta[b]pyrrole-3-carboxamide

: 1088714-18-4
2-(4-ethynyl-2-fluorophenylamino)-N-(2-hydroxyethoxy)-1-methyl-6-oxo-1,4,5,6-tetrahydrocyclopenta[b]pyrrole-3-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: copper(l) iodide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine / tetrahydrofuran

2: tetrabutyl ammonium fluoride / tetrahydrofuran

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; copper(l) iodide; tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran; 1: Sonogashira coupling;
DOI:10.1016/j.bmcl.2012.02.026

Reference yield:

: 29632-74-4
2-fluro-4-iodoaniline

: 1088714-18-4
2-(4-ethynyl-2-fluorophenylamino)-N-(2-hydroxyethoxy)-1-methyl-6-oxo-1,4,5,6-tetrahydrocyclopenta[b]pyrrole-3-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: ethyl acetate / Reflux

2.1: sodium hydrogencarbonate / tetrahydrofuran / Reflux

2.2: Reflux

3.1: caesium carbonate / N,N-dimethyl-formamide

4.1: water; sodium hydroxide / tetrahydrofuran; methanol

5.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide

6.1: copper(l) iodide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine / tetrahydrofuran

7.1: tetrabutyl ammonium fluoride / tetrahydrofuran

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; copper(l) iodide; tetrabutyl ammonium fluoride; water; sodium hydrogencarbonate; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; ethyl acetate; N,N-dimethyl-formamide; 6.1: Sonogashira coupling;
DOI:10.1016/j.bmcl.2012.02.026