4-(4-((8-ethoxy-2-methyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)methyl)piperazin-1-yl)-N-ethyl-3-methylbenzamide

Base Information

Chemical Name:4-(4-((8-ethoxy-2-methyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)methyl)piperazin-1-yl)-N-ethyl-3-methylbenzamide
CAS No.:1246085-44-8
Molecular Formula:C₂₆H₃₄N₄O₄
Molecular Weight:466.58
Hs Code.:

Synonyms:4-(4-((8-ethoxy-2-methyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)methyl)piperazin-1-yl)-N-ethyl-3-methylbenzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(4-((8-ethoxy-2-methyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)methyl)piperazin-1-yl)-N-ethyl-3-methylbenzamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 4-(4-((8-ethoxy-2-methyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)methyl)piperazin-1-yl)-N-ethyl-3-methylbenzamide

There total 10 articles about 4-(4-((8-ethoxy-2-methyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)methyl)piperazin-1-yl)-N-ethyl-3-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: N-ethyl-3-methyl-4-(piperazin-1-yl)benzamide hydrochloride

: 1246085-69-7
8-ethoxy-2-methyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-6-carbaldehyde

: 1246085-44-8
4-(4-((8-ethoxy-2-methyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)methyl)piperazin-1-yl)-N-ethyl-3-methylbenzamide

Guidance literature:: With sodium tris(acetoxy)borohydride; acetic acid; In 1,2-dichloro-ethane; at 23 ℃; for 18h;
DOI:10.1016/j.bmcl.2013.06.055

Reference yield:

: 185147-08-4
4-fluoro-3-methylbenzonitrile

: 1246085-44-8
4-(4-((8-ethoxy-2-methyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)methyl)piperazin-1-yl)-N-ethyl-3-methylbenzamide

Guidance literature:: Multi-step reaction with 6 steps

1: dimethyl sulfoxide / 16 h / 140 °C

2: tetrahydrofuran; methanol / 18.25 h / 10 - 23 °C

3: sodium hydroxide / ethanol; water / 10 h / 90 °C

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / N,N-dimethyl-formamide / 2 h / 20 °C

5: hydrogenchloride / 1,4-dioxane / 0.5 h

6: sodium tris(acetoxy)borohydride; acetic acid / 1,2-dichloro-ethane / 18 h / 23 °C

With 4-methyl-morpholine; hydrogenchloride; sodium tris(acetoxy)borohydride; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water; dimethyl sulfoxide; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2013.06.055

Reference yield:

: 1246081-95-7
8-methoxy-2-methyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-6-carbaldehyde

: 1246085-44-8
4-(4-((8-ethoxy-2-methyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)methyl)piperazin-1-yl)-N-ethyl-3-methylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: boron tribromide / dichloromethane / -10 - 23 °C

2: caesium carbonate / N,N-dimethyl-formamide / 20 h / 23 °C / Cooling with ice

3: sodium tris(acetoxy)borohydride; acetic acid / 1,2-dichloro-ethane / 18 h / 23 °C

With boron tribromide; sodium tris(acetoxy)borohydride; caesium carbonate; acetic acid; In dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2013.06.055