N-tert-butyl 2-(3-amino-2-oxo-5-phenyl-7-methyl-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)ethanoic acid amide

Base Information

Chemical Name:N-tert-butyl 2-(3-amino-2-oxo-5-phenyl-7-methyl-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)ethanoic acid amide
CAS No.:152607-51-7
Molecular Formula:C₂₃H₂₉N₃O₂
Molecular Weight:379.502
Hs Code.:

Synonyms:N-tert-butyl 2-(3-amino-2-oxo-5-phenyl-7-methyl-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)ethanoic acid amide

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Chemical Property of N-tert-butyl 2-(3-amino-2-oxo-5-phenyl-7-methyl-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)ethanoic acid amide

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Technology Process of N-tert-butyl 2-(3-amino-2-oxo-5-phenyl-7-methyl-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)ethanoic acid amide

There total 7 articles about N-tert-butyl 2-(3-amino-2-oxo-5-phenyl-7-methyl-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)ethanoic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

: 152607-50-6
N-tert-butyl 2-(3-azido-2-oxo-5-phenyl-7-methyl-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)ethanoic acid amide

: 152607-51-7
N-tert-butyl 2-(3-amino-2-oxo-5-phenyl-7-methyl-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)ethanoic acid amide

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; for 5h; under 2844.3 Torr;
DOI:10.1021/jm00048a015

Reference yield: 29.0%

: 152607-51-7
N-tert-butyl 2-(3-amino-2-oxo-5-phenyl-7-methyl-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)ethanoic acid amide

Guidance literature:

Reference yield:

: 15678-99-6
N-tert-butylchloroacetamide

: 152607-51-7
N-tert-butyl 2-(3-amino-2-oxo-5-phenyl-7-methyl-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)ethanoic acid amide

Guidance literature:: Multi-step reaction with 4 steps

1: 44 percent / NaI / acetone / 3 h / Heating

2: 1.) LiN(SiMe₃)2 / 1.) THF, 5 min, 2.) THF, DMSO, RT, 1 h

3: 81 percent / NaN₃ / dimethylformamide / 14 h / 70 °C

4: 29 percent / H₂ / 5percent Pd/C / methanol / 5 h / 2844.3 Torr

With sodium azide; hydrogen; sodium iodide; lithium hexamethyldisilazane; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm00048a015