(-)-(3'S,4S,5S)-2,2-Dimethyl-4-phenyl-N-(1'-phenylpent-1'-in-3'-yl)-1,3-dioxan-5-amin

Base Information

Chemical Name:(-)-(3'S,4S,5S)-2,2-Dimethyl-4-phenyl-N-(1'-phenylpent-1'-in-3'-yl)-1,3-dioxan-5-amin
CAS No.:147722-43-8
Molecular Formula:C₂₃H₂₇NO₂
Molecular Weight:349.473
Hs Code.:

Synonyms:(-)-(3'S,4S,5S)-2,2-Dimethyl-4-phenyl-N-(1'-phenylpent-1'-in-3'-yl)-1,3-dioxan-5-amin

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Chemical Property of (-)-(3'S,4S,5S)-2,2-Dimethyl-4-phenyl-N-(1'-phenylpent-1'-in-3'-yl)-1,3-dioxan-5-amin

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Technology Process of (-)-(3'S,4S,5S)-2,2-Dimethyl-4-phenyl-N-(1'-phenylpent-1'-in-3'-yl)-1,3-dioxan-5-amin

There total 3 articles about (-)-(3'S,4S,5S)-2,2-Dimethyl-4-phenyl-N-(1'-phenylpent-1'-in-3'-yl)-1,3-dioxan-5-amin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 811-49-4
ethyllithium

: 147722-38-1
(-)-(4S,5S)-2,2-Dimethyl-4-phenyl-N-(3'-phenylprop-2'-in-1'-yliden)-1,3-dioxan-5-amin

: 147722-43-8
(-)-(3'S,4S,5S)-2,2-Dimethyl-4-phenyl-N-(1'-phenylpent-1'-in-3'-yl)-1,3-dioxan-5-amin

Guidance literature:: With cerium(III) chloride; In tetrahydrofuran; diethyl ether; -100 deg C, 1 h; -100 deg C to -10 - 0 deg C, 12 h;
DOI:10.1002/hlca.19950780419

Reference yield:

: 2579-22-8
Phenylpropargyl aldehyde

: 147722-43-8
(-)-(3'S,4S,5S)-2,2-Dimethyl-4-phenyl-N-(1'-phenylpent-1'-in-3'-yl)-1,3-dioxan-5-amin

Guidance literature:: Multi-step reaction with 2 steps

1: cyclohexane / 2 h / Heating

2: 1) CeCl₃ / 1) Et₂O, THF, -78 deg C, 2 h, 2a) THF, -100 deg C, 1 h, 2b) to 0 deg C, 12 h

With cerium(III) chloride; In cyclohexane;
DOI:10.1002/hlca.19930760123

Reference yield:

: 35019-66-0
(4S,5S)-2,2-dimethyl-4-phenyl-1,3-dioxan-5-amine

: 147722-43-8
(-)-(3'S,4S,5S)-2,2-Dimethyl-4-phenyl-N-(1'-phenylpent-1'-in-3'-yl)-1,3-dioxan-5-amin

Guidance literature:: Multi-step reaction with 2 steps

1: cyclohexane / 2 h / Heating

2: 1) CeCl₃ / 1) Et₂O, THF, -78 deg C, 2 h, 2a) THF, -100 deg C, 1 h, 2b) to 0 deg C, 12 h

With cerium(III) chloride; In cyclohexane;
DOI:10.1002/hlca.19930760123