2-(4-methoxy-phenyl)-1-{2-[4-(4-methylpyridin-2-yl)piperazin-1-yl]ethyl}-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinoline

Base Information

• Chemical Name: 2-(4-methoxy-phenyl)-1-{2-[4-(4-methylpyridin-2-yl)piperazin-1-yl]ethyl}-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinoline
• CAS No.: 148489-98-9
• Molecular Formula: C₃₀H₃₄N₄O
• Molecular Weight: 466.626

Synonyms:2-(4-methoxy-phenyl)-1-{2-[4-(4-methylpyridin-2-yl)piperazin-1-yl]ethyl}-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinoline

Chemical Property of 2-(4-methoxy-phenyl)-1-{2-[4-(4-methylpyridin-2-yl)piperazin-1-yl]ethyl}-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinoline

Chemical Property:

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Technology Process of 2-(4-methoxy-phenyl)-1-{2-[4-(4-methylpyridin-2-yl)piperazin-1-yl]ethyl}-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinoline

There total 2 articles about 2-(4-methoxy-phenyl)-1-{2-[4-(4-methylpyridin-2-yl)piperazin-1-yl]ethyl}-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(4-methylpyridin-2-yl)-piperazine (34803-67-3) + 1-(2-Bromo-ethyl)-2-(4-methoxy-phenyl)-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinoline → 2-(4-methoxy-phenyl)-1-{2-[4-(4-methylpyridin-2-yl)piperazin-1-yl]ethyl}-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinoline (148489-98-9)

Guidance literature:

With triethylamine; potassium iodide; In N,N-dimethyl-formamide; at 90 ℃; for 2h; Yield given;

DOI:10.1021/jm00004a013

Reference yield:

→ 2-(4-Methoxyphenyl)-1-{2-[4-methylpyridin-2-yl)piperazin-1-yl]ethyl-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinoline + 2-(4-methoxy-phenyl)-1-{2-[4-(4-methylpyridin-2-yl)piperazin-1-yl]ethyl}-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinoline (148489-98-9)

Guidance literature:

Reference yield:

2-(4-methoxy-phenyl)-1-{2-[4-(4-methylpyridin-2-yl)piperazin-1-yl]ethyl}-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinoline (148489-98-9) → 2-(4-Hydroxyphenyl)-1-{2-[4-(4-methylpyridin-2-yl)-piperazin-1-yl)ethyl}-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinoline

Guidance literature:

With boron tribromide; In dichloromethane; at -40 - 20 ℃; Yield given;

DOI:10.1021/jm00004a013

upstream raw materials:

N-(4-methylpyridin-2-yl)-piperazine

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