3-[2-(3-chlorophenyl)ethyl]-2-[hydroxy(1-methylpiperidin-4-yl)methyl]-5-phenylpyridine

Base Information

Chemical Name:3-[2-(3-chlorophenyl)ethyl]-2-[hydroxy(1-methylpiperidin-4-yl)methyl]-5-phenylpyridine
CAS No.:855200-30-5
Molecular Formula:C₂₆H₂₉ClN₂O
Molecular Weight:420.982
Hs Code.:

Synonyms:3-[2-(3-chlorophenyl)ethyl]-2-[hydroxy(1-methylpiperidin-4-yl)methyl]-5-phenylpyridine

Suppliers and Price of 3-[2-(3-chlorophenyl)ethyl]-2-[hydroxy(1-methylpiperidin-4-yl)methyl]-5-phenylpyridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-[2-(3-chlorophenyl)ethyl]-2-[hydroxy(1-methylpiperidin-4-yl)methyl]-5-phenylpyridine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-[2-(3-chlorophenyl)ethyl]-2-[hydroxy(1-methylpiperidin-4-yl)methyl]-5-phenylpyridine

There total 6 articles about 3-[2-(3-chlorophenyl)ethyl]-2-[hydroxy(1-methylpiperidin-4-yl)methyl]-5-phenylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 851854-07-4
1-chloro-3-(4,4-dibromobut-3-en-1-yl)benzene

: 855200-30-5
3-[2-(3-chlorophenyl)ethyl]-2-[hydroxy(1-methylpiperidin-4-yl)methyl]-5-phenylpyridine

Guidance literature:: Multi-step reaction with 4 steps

1.1: nBuLi / tetrahydrofuran

1.2: 71 percent / tetrahydrofuran

2.1: Ti(O-i-Pr)4; i-PrMgCl / diethyl ether / 5.5 h / -50 °C

2.2: diethyl ether / 3 h / -50 °C

2.3: 61 percent / diethyl ether / 5 h / 20 °C

3.1: 94 percent / Cp₂Zr(H)Cl / tetrahydrofuran / 0.5 h / 20 °C

4.1: 72 percent / tetrahydrofuran / 0.17 h / 20 °C

With titanium(IV) isopropylate; Schwartz's reagent; n-butyllithium; isopropylmagnesium chloride; In tetrahydrofuran; diethyl ether;
DOI:10.1021/ja050261e

Reference yield:

: 855200-21-4
N,N-diethyl-5-(3-chlorophenyl)-2-pentynamide

: 855200-30-5
3-[2-(3-chlorophenyl)ethyl]-2-[hydroxy(1-methylpiperidin-4-yl)methyl]-5-phenylpyridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: Ti(O-i-Pr)4; i-PrMgCl / diethyl ether / 5.5 h / -50 °C

1.2: diethyl ether / 3 h / -50 °C

1.3: 61 percent / diethyl ether / 5 h / 20 °C

2.1: 94 percent / Cp₂Zr(H)Cl / tetrahydrofuran / 0.5 h / 20 °C

3.1: 72 percent / tetrahydrofuran / 0.17 h / 20 °C

With titanium(IV) isopropylate; Schwartz's reagent; isopropylmagnesium chloride; In tetrahydrofuran; diethyl ether;
DOI:10.1021/ja050261e

Reference yield:

: 855200-24-7
N,N-diethyl-3-[2-(3-chlorophenyl)ethyl]-5-phenyl-2-picolinamide

: 855200-30-5
3-[2-(3-chlorophenyl)ethyl]-2-[hydroxy(1-methylpiperidin-4-yl)methyl]-5-phenylpyridine

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / Cp₂Zr(H)Cl / tetrahydrofuran / 0.5 h / 20 °C

2: 72 percent / tetrahydrofuran / 0.17 h / 20 °C

With Schwartz's reagent; In tetrahydrofuran;
DOI:10.1021/ja050261e