7-benzyloxy-3-[2-(3,4-dimethoxyphenyl)ethyl]-8-methoxy-1-[4-methoxy-3-(methoxymethoxy)phenyl]-[1]benzopyrano[3,4-b]pyrrol-4(3H)-one

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Chemical Name:7-benzyloxy-3-[2-(3,4-dimethoxyphenyl)ethyl]-8-methoxy-1-[4-methoxy-3-(methoxymethoxy)phenyl]-[1]benzopyrano[3,4-b]pyrrol-4(3H)-one
CAS No.:1225441-59-7
Molecular Formula:C₃₈H₃₇NO₉
Molecular Weight:651.713
Hs Code.:

Synonyms:7-benzyloxy-3-[2-(3,4-dimethoxyphenyl)ethyl]-8-methoxy-1-[4-methoxy-3-(methoxymethoxy)phenyl]-[1]benzopyrano[3,4-b]pyrrol-4(3H)-one

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Chemical Property of 7-benzyloxy-3-[2-(3,4-dimethoxyphenyl)ethyl]-8-methoxy-1-[4-methoxy-3-(methoxymethoxy)phenyl]-[1]benzopyrano[3,4-b]pyrrol-4(3H)-one

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Technology Process of 7-benzyloxy-3-[2-(3,4-dimethoxyphenyl)ethyl]-8-methoxy-1-[4-methoxy-3-(methoxymethoxy)phenyl]-[1]benzopyrano[3,4-b]pyrrol-4(3H)-one

There total 18 articles about 7-benzyloxy-3-[2-(3,4-dimethoxyphenyl)ethyl]-8-methoxy-1-[4-methoxy-3-(methoxymethoxy)phenyl]-[1]benzopyrano[3,4-b]pyrrol-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1225441-58-6
7-benzyloxy-3-[2-(3,4-dimethoxyphenyl)ethyl]-3,4-dihydro-8-methoxy-1-[4-methoxy-3-(methoxymethoxy)phenyl]-4-oxo-[1]benzopyrano[3,4-b]pyrrole-2-carboxylic acid

: 1225441-59-7
7-benzyloxy-3-[2-(3,4-dimethoxyphenyl)ethyl]-8-methoxy-1-[4-methoxy-3-(methoxymethoxy)phenyl]-[1]benzopyrano[3,4-b]pyrrol-4(3H)-one

Guidance literature:: With quinoline; copper(II) oxide; at 220 ℃; for 0.166667h; Inert atmosphere;
DOI:10.1016/j.bmc.2011.10.030

Reference yield:

: 37942-01-1
5-bromo-2-methoxyphenol

: 1225441-59-7
7-benzyloxy-3-[2-(3,4-dimethoxyphenyl)ethyl]-8-methoxy-1-[4-methoxy-3-(methoxymethoxy)phenyl]-[1]benzopyrano[3,4-b]pyrrol-4(3H)-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / acetone / 9 h / Inert atmosphere; Reflux

2.1: tert.-butyl lithium / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

2.2: 2 h / -78 - 20 °C

2.3: pH 3

3.1: dichloromethane / 26 h / 20 °C

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / tetrahydrofuran; water / 3 h / Reflux; Inert atmosphere

5.1: potassium hydroxide / ethanol; water / 2 h / Reflux

6.1: pyridinium p-toluenesulfonate / dichloromethane / 8 h / Reflux

7.1: quinoline; copper(II) oxide / 0.17 h / 220 °C / Inert atmosphere

With quinoline; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tert.-butyl lithium; pyridinium p-toluenesulfonate; sodium carbonate; potassium carbonate; copper(II) oxide; potassium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; water; acetone; 4.1: Suzuki-Miyaura coupling;
DOI:10.1016/j.bmc.2011.10.030

Reference yield:

: 1225441-54-2
1-benzyloxy-4-bromo-2-methoxy-5-(methoxymethoxy)benzene

: 1225441-59-7
7-benzyloxy-3-[2-(3,4-dimethoxyphenyl)ethyl]-8-methoxy-1-[4-methoxy-3-(methoxymethoxy)phenyl]-[1]benzopyrano[3,4-b]pyrrol-4(3H)-one

Guidance literature:: Multi-step reaction with 8 steps

1.1: tert.-butyl lithium / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

1.2: 2 h / -78 - 20 °C

1.3: pH 3

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / tetrahydrofuran; water / 3 h / Reflux; Inert atmosphere

3.1: hydrogenchloride / methanol / 3 h / 20 °C

4.1: toluene-4-sulfonic acid / dichloromethane / 3.5 h / Reflux

5.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / tetrahydrofuran; water / 3 h / Reflux; Inert atmosphere

6.1: potassium hydroxide / ethanol; water / 2 h / Reflux

7.1: pyridinium p-toluenesulfonate / dichloromethane / 8 h / Reflux

8.1: quinoline; copper(II) oxide / 0.17 h / 220 °C / Inert atmosphere

With quinoline; hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tert.-butyl lithium; pyridinium p-toluenesulfonate; sodium carbonate; toluene-4-sulfonic acid; copper(II) oxide; potassium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; 2.1: Suzuki-Miyaura coupling / 5.1: Suzuki-Miyaura coupling;
DOI:10.1016/j.bmc.2011.10.030