1-O-palmitoyl-2-O-[12-[N-(4-azido-2,3,5,6-tetrafluorobenzoyl)]amidododecanoyl]-sn-glycero-3-phosphocholine

Base Information

• Chemical Name: 1-O-palmitoyl-2-O-[12-[N-(4-azido-2,3,5,6-tetrafluorobenzoyl)]amidododecanoyl]-sn-glycero-3-phosphocholine
• CAS No.: 423756-19-8
• Molecular Formula: C₄₃H₇₂F₄N₅O₉P
• Molecular Weight: 910.04
• Mol file: 423756-19-8.mol

Synonyms:1-O-palmitoyl-2-O-[12-[N-(4-azido-2,3,5,6-tetrafluorobenzoyl)]amidododecanoyl]-sn-glycero-3-phosphocholine

Chemical Property of 1-O-palmitoyl-2-O-[12-[N-(4-azido-2,3,5,6-tetrafluorobenzoyl)]amidododecanoyl]-sn-glycero-3-phosphocholine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-O-palmitoyl-2-O-[12-[N-(4-azido-2,3,5,6-tetrafluorobenzoyl)]amidododecanoyl]-sn-glycero-3-phosphocholine

There total 4 articles about 1-O-palmitoyl-2-O-[12-[N-(4-azido-2,3,5,6-tetrafluorobenzoyl)]amidododecanoyl]-sn-glycero-3-phosphocholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.2%

1-palmitoyl-sn-glycero-3-phosphocholine (17364-16-8,17364-17-9,17364-18-0,14863-27-5) + 12-[N-(4-azido-2,3,5,6-tetrafluorobenzoyl)]amidododecanoic acid (254968-74-6) → 1-O-palmitoyl-2-O-[12-[N-(4-azido-2,3,5,6-tetrafluorobenzoyl)]amidododecanoyl]-sn-glycero-3-phosphocholine (423756-19-8)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; for 40h;

DOI:10.1021/jm011032f

Reference yield:

1-palmitoyl-sn-glycero-3-phosphocholine (17364-16-8,17364-17-9,17364-18-0,14863-27-5) + C38H46F8N8O5 → 1-O-palmitoyl-2-O-[12-[N-(4-azido-2,3,5,6-tetrafluorobenzoyl)]amidododecanoyl]-sn-glycero-3-phosphocholine (423756-19-8)

Guidance literature:

With dmap; In chloroform; at 20 ℃; for 40h;

DOI:10.1021/jm011032f

Reference yield:

succinimidyl 4-azido-2,3,5,6-tetrafluorobenzoate (126695-58-7) → 1-O-palmitoyl-2-O-[12-[N-(4-azido-2,3,5,6-tetrafluorobenzoyl)]amidododecanoyl]-sn-glycero-3-phosphocholine (423756-19-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / dioxane / 4 h / 50 - 60 °C

2: 85.2 percent / N,N-dicyclohexylcarbodiimide; 4-(N,N-dimethylamino)pyridine / CH₂Cl₂ / 40 h

With dmap; dicyclohexyl-carbodiimide; In 1,4-dioxane; dichloromethane;

DOI:10.1021/jm011032f

upstream raw materials:

1-palmitoyl-sn-glycero-3-phosphocholine

12-[N-(4-azido-2,3,5,6-tetrafluorobenzoyl)]amidododecanoic acid

succinimidyl 4-azido-2,3,5,6-tetrafluorobenzoate

12-Aminododecanoic acid