N-α--L-phenylalanyl>-N^α-methyl-N^im-tosyl-L-histidyl>-5(S)-amino-4(S)-hydroxy-2(S)-isopropyl-7-methyloctanoyl>-L-isoleucyl>(1-oxo-2-pyridyl)methylamine

Base Information

• Chemical Name: N-α--L-phenylalanyl>-N^α-methyl-N^im-tosyl-L-histidyl>-5(S)-amino-4(S)-hydroxy-2(S)-isopropyl-7-methyloctanoyl>-L-isoleucyl>(1-oxo-2-pyridyl)methylamine
• CAS No.: 128657-34-1
• Molecular Formula: C₅₀H₇₅N₉O₉
• Molecular Weight: 946.2

Synonyms:N-α--L-phenylalanyl>-N^α-methyl-N^im-tosyl-L-histidyl>-5(S)-amino-4(S)-hydroxy-2(S)-isopropyl-7-methyloctanoyl>-L-isoleucyl>(1-oxo-2-pyridyl)methylamine

Chemical Property of N-α--L-phenylalanyl>-N^α-methyl-N^im-tosyl-L-histidyl>-5(S)-amino-4(S)-hydroxy-2(S)-isopropyl-7-methyloctanoyl>-L-isoleucyl>(1-oxo-2-pyridyl)methylamine

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Technology Process of N-α--L-phenylalanyl>-N^α-methyl-N^im-tosyl-L-histidyl>-5(S)-amino-4(S)-hydroxy-2(S)-isopropyl-7-methyloctanoyl>-L-isoleucyl>(1-oxo-2-pyridyl)methylamine

There total 2 articles about N-α--L-phenylalanyl>-N^α-methyl-N^im-tosyl-L-histidyl>-5(S)-amino-4(S)-hydroxy-2(S)-isopropyl-7-methyloctanoyl>-L-isoleucyl>(1-oxo-2-pyridyl)methylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

N-α--L-phenylalanyl>-Nα-methyl-Nim-tosyl-L-histidyl>-5(S)-amino-4(S)-hydroxy-2(S)-isopropyl-7-methyloctanoyl>-L-isoleucyl>(1-oxo-2-pyridyl)methylamine (130985-35-2) → N-α--L-phenylalanyl>-Nα-methyl-Nim-tosyl-L-histidyl>-5(S)-amino-4(S)-hydroxy-2(S)-isopropyl-7-methyloctanoyl>-L-isoleucyl>(1-oxo-2-pyridyl)methylamine (128657-34-1)

Guidance literature:

With benzotriazol-1-ol; In methanol; for 4h;

DOI:10.1021/jm00106a026

Reference yield:

N-α--L-phenylalanyl>-Nα-methyl-Nim-tosyl-L-histidyl>-5(S)-amino-4(S)-hydroxy-2(S)-isopropyl-7-methyloctanoyl>-L-isoleucyl>-2-pyridylmethylamine (130985-34-1) → N-α--L-phenylalanyl>-Nα-methyl-Nim-tosyl-L-histidyl>-5(S)-amino-4(S)-hydroxy-2(S)-isopropyl-7-methyloctanoyl>-L-isoleucyl>(1-oxo-2-pyridyl)methylamine (128657-34-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 72 percent / NaHCO₃, m-chloroperbenzoic acid / CH₂Cl₂ / 1 h

2: 80 percent / 1-hydroxybenzotriazole / methanol / 4 h

With sodium hydrogencarbonate; benzotriazol-1-ol; 3-chloro-benzenecarboperoxoic acid; In methanol; dichloromethane;

DOI:10.1021/jm00106a026

Reference yield:

N-α--L-phenylalanyl>-Nα-methyl-Nim-tosyl-L-histidyl>-5(S)-amino-4(S)-hydroxy-2(S)-isopropyl-7-methyloctanoyl>-L-isoleucyl>(1-oxo-2-pyridyl)methylamine (128657-34-1) → (S)-Pyrrolidine-2-carboxylic acid ((S)-1-{[(S)-1-((1S,2S,4S)-2-hydroxy-1-isobutyl-5-methyl-4-{(1S,2S)-2-methyl-1-[methyl-(1-oxy-pyridin-2-yl)-carbamoyl]-butylcarbamoyl}-hexylcarbamoyl)-2-(1H-imidazol-4-yl)-ethyl]-methyl-carbamoyl}-2-phenyl-ethyl)-amide

Guidance literature:

With trifluoroacetic acid; In dichloromethane; for 1h;

DOI:10.1021/jm00106a026

upstream raw materials:

N-α--L-phenylalanyl>-N^α-methyl-N^im-tosyl-L-histidyl>-5(S)-amino-4(S)-hydroxy-2(S)-isopropyl-7-methyloctanoyl>-L-isoleucyl>(1-oxo-2-pyridyl)methylamine

N-α--L-phenylalanyl>-N^α-methyl-N^im-tosyl-L-histidyl>-5(S)-amino-4(S)-hydroxy-2(S)-isopropyl-7-methyloctanoyl>-L-isoleucyl>-2-pyridylmethylamine

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