Technology Process of (2S,3S,4R)-2-(benzyloxy)methyl-3-((tert-butyldimethylsilyl)oxy)-2,4-dimethylpentanedial
There total 7 articles about (2S,3S,4R)-2-(benzyloxy)methyl-3-((tert-butyldimethylsilyl)oxy)-2,4-dimethylpentanedial which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
2,6-dimethylpyridine; [bis(acetoxy)iodo]benzene;
In
dichloromethane;
at 20 ℃;
for 0.5h;
Inert atmosphere;
DOI:10.1021/ja3032345
- Guidance literature:
-
Multi-step reaction with 5 steps
1: diisobutylaluminium hydride / hexane; dichloromethane / 0.17 h / Inert atmosphere
2: tetrakis(triphenylphosphine) palladium(0); triethylamine / N,N-dimethyl-formamide / 3 h / 20 °C / Inert atmosphere
3: potassium hydride / tetrahydrofuran; mineral oil / 1 h / 0 - 20 °C / Inert atmosphere
4: 2,6-dimethylpyridine; osmium(VIII) oxide; 4-methylmorpholine N-oxide / water; acetone / 12 h / 20 °C / Inert atmosphere
5: 2,6-dimethylpyridine; [bis(acetoxy)iodo]benzene / dichloromethane / 0.5 h / 20 °C / Inert atmosphere
With
2,6-dimethylpyridine; osmium(VIII) oxide; tetrakis(triphenylphosphine) palladium(0); [bis(acetoxy)iodo]benzene; potassium hydride; diisobutylaluminium hydride; 4-methylmorpholine N-oxide; triethylamine;
In
tetrahydrofuran; hexane; dichloromethane; water; N,N-dimethyl-formamide; acetone; mineral oil;
DOI:10.1021/ja3032345
- Guidance literature:
-
Multi-step reaction with 8 steps
1: copper(ll) bromide / methanol / 1 h / Inert atmosphere; Reflux
2: C58H58NO2P; copper(II) bis(trifluoromethanesulfonate) / diethyl ether; hexane / 0.5 h / -78 - 20 °C / Inert atmosphere
3: diethyl ether; hexane / 1 h / 20 °C / Inert atmosphere
4: diisobutylaluminium hydride / hexane; dichloromethane / 0.17 h / Inert atmosphere
5: tetrakis(triphenylphosphine) palladium(0); triethylamine / N,N-dimethyl-formamide / 3 h / 20 °C / Inert atmosphere
6: potassium hydride / tetrahydrofuran; mineral oil / 1 h / 0 - 20 °C / Inert atmosphere
7: 2,6-dimethylpyridine; osmium(VIII) oxide; 4-methylmorpholine N-oxide / water; acetone / 12 h / 20 °C / Inert atmosphere
8: 2,6-dimethylpyridine; [bis(acetoxy)iodo]benzene / dichloromethane / 0.5 h / 20 °C / Inert atmosphere
With
2,6-dimethylpyridine; osmium(VIII) oxide; tetrakis(triphenylphosphine) palladium(0); [bis(acetoxy)iodo]benzene; C58H58NO2P; potassium hydride; copper(II) bis(trifluoromethanesulfonate); diisobutylaluminium hydride; 4-methylmorpholine N-oxide; triethylamine; copper(ll) bromide;
In
tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; water; N,N-dimethyl-formamide; acetone; mineral oil;
DOI:10.1021/ja3032345
