3-Bromo-7-chloro-4-hydroxyquinoline

Base Information

Chemical Name:3-Bromo-7-chloro-4-hydroxyquinoline
CAS No.:860715-45-3
Molecular Formula:C9H5 Br Cl N O
Molecular Weight:258.5
Hs Code.:
DSSTox Substance ID:DTXSID30590580
Wikidata:Q82484227
Mol file:860715-45-3.mol

Synonyms:860715-45-3;3-Bromo-7-chloro-4-hydroxyquinoline;3-bromo-7-chloro-1H-quinolin-4-one;3-Bromo-7-chloroquinolin-4-ol;3-Bromo-7-chloro-4-quinolinol;SCHEMBL18283482;DTXSID30590580;3-Bromo-7-chloroquinolin-4(1H)-one;AT11280

Suppliers and Price of 3-Bromo-7-chloro-4-hydroxyquinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
3-BROMO-7-CHLORO-4-HYDROXYQUINOLINE 95.00%
5MG
$ 498.78

Total 7 raw suppliers

Chemical Property of 3-Bromo-7-chloro-4-hydroxyquinoline

Chemical Property:

Vapor Pressure:3.91E-05mmHg at 25°C
Refractive Index:1.72
Boiling Point:342°C at 760 mmHg
Flash Point:160.7°C
PSA：33.12000
Density:1.803g/cm³
LogP:3.35630
XLogP3:3.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:0
Exact Mass:256.92430
Heavy Atom Count:13
Complexity:266

Purity/Quality:

97% ^*data from raw suppliers

3-BROMO-7-CHLORO-4-HYDROXYQUINOLINE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC2=C(C=C1Cl)NC=C(C2=O)Br
Uses 3-Bromo-7-chloro-4-quinolinol is an intermediate in the synthesis of 3-Bromo-7-chloro Hydroxychloroquine (B258260) which is an impurity of Hydroxychloroquine (B419750). Hydroxychloroquine is an antimalarial; antirheumatic; lupus erythematosus suppressant.

Technology Process of 3-Bromo-7-chloro-4-hydroxyquinoline

There total 4 articles about 3-Bromo-7-chloro-4-hydroxyquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 86-99-7
7-chloro-4-hydroxylquinoline

: 860715-45-3
7-chloro-3-bromoquinolin-4-ol

Guidance literature:: With N-Bromosuccinimide; acetic acid; at 60 ℃; for 5h;

Reference yield:

: 858195-34-3
3-bromo-7-chloro-4-hydroxy-quinoline-2-carboxylic acid

: 860715-45-3
7-chloro-3-bromoquinolin-4-ol

Guidance literature:: With diphenylether; biphenyl; at 200 ℃;
DOI:10.1021/ja01216a044

Reference yield:

: 21640-97-1
7-chloro-4-hydroxy-quinoline-2-carboxylic acid ethyl ester

: 860715-45-3
7-chloro-3-bromoquinolin-4-ol

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid; iodine; bromine

2: aqueous NaOH

3: diphenyl ether; biphenyl / 200 °C

With sodium hydroxide; diphenylether; biphenyl; bromine; iodine; acetic acid;
DOI:10.1021/ja01216a044