(S)-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)(2-(2-(trifluoromethoxy)benzyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)methanone

Base Information

Chemical Name:(S)-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)(2-(2-(trifluoromethoxy)benzyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)methanone
CAS No.:1308337-91-8
Molecular Formula:C₂₉H₂₉F₃N₂O₄
Molecular Weight:526.555
Hs Code.:

Synonyms:(S)-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)(2-(2-(trifluoromethoxy)benzyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)methanone

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Chemical Property of (S)-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)(2-(2-(trifluoromethoxy)benzyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)methanone

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Technology Process of (S)-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)(2-(2-(trifluoromethoxy)benzyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)methanone

There total 4 articles about (S)-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)(2-(2-(trifluoromethoxy)benzyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 1308338-92-2
(S)-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)(1,2,3,4-tetrahydroisoquinolin-3-yl)methanone

: 94651-33-9
2-(trifluoromethoxy)benzaldehyde

: 1308337-91-8
(S)-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)(2-(2-(trifluoromethoxy)benzyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)methanone

Guidance literature:: (S)-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)(1,2,3,4-tetrahydroisoquinolin-3-yl)methanone; 2-(trifluoromethoxy)benzaldehyde; With sodium tris(acetoxy)borohydride; In N,N-dimethyl-formamide; at 100 ℃; for 0.0833333h; Microwave irradiation;

With water; In N,N-dimethyl-formamide;

Reference yield:

: 74163-81-8
L-Tic-OH

: 1308337-91-8
(S)-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)(2-(2-(trifluoromethoxy)benzyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)methanone

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydrogencarbonate / 1,4-dioxane; water

2: triethylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / dichloromethane; ethyl acetate / 1 h

3: trifluoroacetic acid / dichloromethane

4: sodium tris(acetoxy)borohydride / N,N-dimethyl-formamide / 0.08 h / 100 °C / Microwave irradiation

With sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1308338-90-0
(S)-tert-butyl 3-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

: 1308337-91-8
(S)-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)(2-(2-(trifluoromethoxy)benzyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane

2: sodium tris(acetoxy)borohydride / N,N-dimethyl-formamide / 0.08 h / 100 °C / Microwave irradiation

With sodium tris(acetoxy)borohydride; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;