5'-O-t-butyldiphenylsilyl-2',3'-dideoxy-2',3'-diiodo-2',3'-secoadenosine

Base Information

Chemical Name:5'-O-t-butyldiphenylsilyl-2',3'-dideoxy-2',3'-diiodo-2',3'-secoadenosine
CAS No.:119923-12-5
Molecular Formula:C₂₆H₃₁I₂N₅O₂Si
Molecular Weight:727.459
Hs Code.:

Synonyms:5'-O-t-butyldiphenylsilyl-2',3'-dideoxy-2',3'-diiodo-2',3'-secoadenosine

Suppliers and Price of 5'-O-t-butyldiphenylsilyl-2',3'-dideoxy-2',3'-diiodo-2',3'-secoadenosine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5'-O-t-butyldiphenylsilyl-2',3'-dideoxy-2',3'-diiodo-2',3'-secoadenosine

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Technology Process of 5'-O-t-butyldiphenylsilyl-2',3'-dideoxy-2',3'-diiodo-2',3'-secoadenosine

There total 7 articles about 5'-O-t-butyldiphenylsilyl-2',3'-dideoxy-2',3'-diiodo-2',3'-secoadenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 119898-73-6
5'-O-t-butyldiphenylsilyl-2',3'-di-O-mesyl-2',3'-secoadenosine

: 119923-12-5
5'-O-t-butyldiphenylsilyl-2',3'-dideoxy-2',3'-diiodo-2',3'-secoadenosine

: 119898-78-1
5'-O-t-butyldiphenylsilyl-3'-deoxy-3'-iodo-2'-O-mesyl-2',3'-secoadenosine

Guidance literature:: With sodium iodide; In N,N-dimethyl-formamide; at 100 ℃; for 7h;
DOI:10.1016/S0040-4020(01)89829-X

Reference yield: 43.0%

: 119898-69-0
5'-O-t-butyldiphenylsilyl-2',3'-secoadenosine

: 119923-12-5
5'-O-t-butyldiphenylsilyl-2',3'-dideoxy-2',3'-diiodo-2',3'-secoadenosine

: 119898-77-0
5'-O-t-butyldiphenylsilyl-3'-deoxy-3'-iodo-2',3'-secoadenosine 2'-(phenyl methylphosphonate)

Guidance literature:: With methyl-triphenylphosphonium iodide; In N,N-dimethyl-formamide; for 0.0833333h;
DOI:10.1016/S0040-4020(01)89829-X

Reference yield:

: 119898-65-6
(2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-((tert-butyldiphenylsilyloxy)methyl)tetrahydrofuran-3,4-diol

: 119923-12-5
5'-O-t-butyldiphenylsilyl-2',3'-dideoxy-2',3'-diiodo-2',3'-secoadenosine

Guidance literature:: Multi-step reaction with 3 steps

1: 89 percent / sodium periodate / acetone; H₂O / 15 °C / dark

2: 83 percent / sodium borohydride / ethanol; H₂O / Ambient temperature; dark

3: 11 percent / dimethylformamide / 0.08 h

With sodium tetrahydroborate; sodium periodate; In ethanol; water; N,N-dimethyl-formamide; acetone;
DOI:10.1016/S0040-4020(01)89829-X