(R)-N-((2R,3S,4R)-2-fluoro-4-methyl-1-phenylhex-5-en-3-yl)-2-methylpropane-2-sulfinamide

Base Information

Chemical Name:(R)-N-((2R,3S,4R)-2-fluoro-4-methyl-1-phenylhex-5-en-3-yl)-2-methylpropane-2-sulfinamide
CAS No.:1335302-49-2
Molecular Formula:C₁₇H₂₆FNOS
Molecular Weight:311.464
Hs Code.:

Synonyms:(R)-N-((2R,3S,4R)-2-fluoro-4-methyl-1-phenylhex-5-en-3-yl)-2-methylpropane-2-sulfinamide

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Chemical Property of (R)-N-((2R,3S,4R)-2-fluoro-4-methyl-1-phenylhex-5-en-3-yl)-2-methylpropane-2-sulfinamide

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Technology Process of (R)-N-((2R,3S,4R)-2-fluoro-4-methyl-1-phenylhex-5-en-3-yl)-2-methylpropane-2-sulfinamide

There total 3 articles about (R)-N-((2R,3S,4R)-2-fluoro-4-methyl-1-phenylhex-5-en-3-yl)-2-methylpropane-2-sulfinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 4784-77-4,29576-14-5,39616-19-8
(E/Z)-crotyl bromide

: (R)-N-((R)-2-fluoro-3-phenylpropylidene)-2-methylpropane-2-sulfinamide

: 1335302-49-2
(R)-N-((2R,3S,4R)-2-fluoro-4-methyl-1-phenylhex-5-en-3-yl)-2-methylpropane-2-sulfinamide

Guidance literature:: With indium; sodium bromide; In water; at 20 ℃; for 12h; diastereoselective reaction;
DOI:10.1021/ol202415j

Reference yield:

: 1095607-09-2
(R)-2-fluoro-3-phenylpropionaldehyde

: 1335302-49-2
(R)-N-((2R,3S,4R)-2-fluoro-4-methyl-1-phenylhex-5-en-3-yl)-2-methylpropane-2-sulfinamide

Guidance literature:: Multi-step reaction with 2 steps

1: titanium(IV) tetraethanolate / tetrahydrofuran / 5 h / 20 °C

2: indium; sodium bromide / water / 12 h / 20 °C

With titanium(IV) tetraethanolate; indium; sodium bromide; In tetrahydrofuran; water;
DOI:10.1021/ol202415j

Reference yield:

: 104-53-0
3-phenyl-propionaldehyde

: 1335302-49-2
(R)-N-((2R,3S,4R)-2-fluoro-4-methyl-1-phenylhex-5-en-3-yl)-2-methylpropane-2-sulfinamide

Guidance literature:: Multi-step reaction with 3 steps

1: (R)-5-benzyl-2,2,3,-trimethylimidazolidin-4-one dichloroacetic acid salt; N-fluorobis(benzenesulfon)imide / tetrahydrofuran; isopropyl alcohol / 12 h / -20 °C

2: titanium(IV) tetraethanolate / tetrahydrofuran / 5 h / 20 °C

3: indium; sodium bromide / water / 12 h / 20 °C

With titanium(IV) tetraethanolate; indium; (R)-5-benzyl-2,2,3,-trimethylimidazolidin-4-one dichloroacetic acid salt; N-fluorobis(benzenesulfon)imide; sodium bromide; In tetrahydrofuran; water; isopropyl alcohol;
DOI:10.1021/ol202415j