(E)-2-Phenyl-ethenesulfonic acid {3-[cyclopropyl-(4-hydroxy-2-oxo-5,6,7,8,9,10-hexahydro-2H-cycloocta[b]pyran-3-yl)-methyl]-phenyl}-amide

Base Information

• Chemical Name: (E)-2-Phenyl-ethenesulfonic acid {3-[cyclopropyl-(4-hydroxy-2-oxo-5,6,7,8,9,10-hexahydro-2H-cycloocta[b]pyran-3-yl)-methyl]-phenyl}-amide
• CAS No.: 166335-75-7
• Molecular Formula: C₂₉H₃₁NO₅S
• Molecular Weight: 505.635

Synonyms:(E)-2-Phenyl-ethenesulfonic acid {3-[cyclopropyl-(4-hydroxy-2-oxo-5,6,7,8,9,10-hexahydro-2H-cycloocta[b]pyran-3-yl)-methyl]-phenyl}-amide

Chemical Property of (E)-2-Phenyl-ethenesulfonic acid {3-[cyclopropyl-(4-hydroxy-2-oxo-5,6,7,8,9,10-hexahydro-2H-cycloocta[b]pyran-3-yl)-methyl]-phenyl}-amide

Chemical Property:

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Safty Information:

• Pictogram(s):  
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Technology Process of (E)-2-Phenyl-ethenesulfonic acid {3-[cyclopropyl-(4-hydroxy-2-oxo-5,6,7,8,9,10-hexahydro-2H-cycloocta[b]pyran-3-yl)-methyl]-phenyl}-amide

There total 4 articles about (E)-2-Phenyl-ethenesulfonic acid {3-[cyclopropyl-(4-hydroxy-2-oxo-5,6,7,8,9,10-hexahydro-2H-cycloocta[b]pyran-3-yl)-methyl]-phenyl}-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5,6,7,8,9,10-Hexahydro-4-hydroxy-2H-cyclooctapyran-2-on (100058-82-0) → (E)-2-Phenyl-ethenesulfonic acid {3-[cyclopropyl-(4-hydroxy-2-oxo-5,6,7,8,9,10-hexahydro-2H-cycloocta[b]pyran-3-yl)-methyl]-phenyl}-amide (166335-75-7)

Guidance literature:

Multi-step reaction with 3 steps

1: p-toluenesulfonic acid / toluene / 72 h / 20 °C

2: H₂ / 10percent Pd/C / methanol / 18 h / 2482.3 Torr

3: pyridine / CH₂Cl₂ / 18 h / Ambient temperature

With pyridine; hydrogen; toluene-4-sulfonic acid; palladium on activated charcoal; In methanol; dichloromethane; toluene;

DOI:10.1021/jm960441m

Reference yield:

m-<(benzyloxycarbonyl)amino>phenyl cyclopropyl carbinol (162174-77-8) → (E)-2-Phenyl-ethenesulfonic acid {3-[cyclopropyl-(4-hydroxy-2-oxo-5,6,7,8,9,10-hexahydro-2H-cycloocta[b]pyran-3-yl)-methyl]-phenyl}-amide (166335-75-7)

Guidance literature:

Multi-step reaction with 3 steps

1: p-toluenesulfonic acid / toluene / 72 h / 20 °C

2: H₂ / 10percent Pd/C / methanol / 18 h / 2482.3 Torr

3: pyridine / CH₂Cl₂ / 18 h / Ambient temperature

With pyridine; hydrogen; toluene-4-sulfonic acid; palladium on activated charcoal; In methanol; dichloromethane; toluene;

DOI:10.1021/jm960441m

Reference yield:

<3-pyran-3-yl)methyl>phenyl>carbamic acid, phenylmethyl ester (166282-28-6,166335-05-3) → (E)-2-Phenyl-ethenesulfonic acid {3-[cyclopropyl-(4-hydroxy-2-oxo-5,6,7,8,9,10-hexahydro-2H-cycloocta[b]pyran-3-yl)-methyl]-phenyl}-amide (166335-75-7)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / 10percent Pd/C / methanol / 18 h / 2482.3 Torr

2: pyridine / CH₂Cl₂ / 18 h / Ambient temperature

With pyridine; hydrogen; palladium on activated charcoal; In methanol; dichloromethane;

DOI:10.1021/jm960441m

upstream raw materials:

β-styrenesulfonyl chloride

3-<(3-aminophenyl)cyclopropylmethyl>-5,6,7,8,9,10-hexahydro-4-hydroxy-2H-cyclooctapyran-2-one

5,6,7,8,9,10-Hexahydro-4-hydroxy-2H-cyclooctapyran-2-on

m-<(benzyloxycarbonyl)amino>phenyl cyclopropyl carbinol

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