3'-O-tert-Butyldimethylsilyl-5'-O-tert-butyldiphenylsilyl-4'-formyl-thymidin

Base Information

Chemical Name:3'-O-tert-Butyldimethylsilyl-5'-O-tert-butyldiphenylsilyl-4'-formyl-thymidin
CAS No.:162052-68-8
Molecular Formula:C₃₃H₄₆N₂O₆Si₂
Molecular Weight:622.909
Hs Code.:

Synonyms:3'-O-tert-Butyldimethylsilyl-5'-O-tert-butyldiphenylsilyl-4'-formyl-thymidin

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Chemical Property of 3'-O-tert-Butyldimethylsilyl-5'-O-tert-butyldiphenylsilyl-4'-formyl-thymidin

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Technology Process of 3'-O-tert-Butyldimethylsilyl-5'-O-tert-butyldiphenylsilyl-4'-formyl-thymidin

There total 6 articles about 3'-O-tert-Butyldimethylsilyl-5'-O-tert-butyldiphenylsilyl-4'-formyl-thymidin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 162052-67-7
1-[(2R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-(tert-butyl-diphenyl-silanyloxymethyl)-5-hydroxymethyl-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

: 162052-68-8
3'-O-tert-Butyldimethylsilyl-5'-O-tert-butyldiphenylsilyl-4'-formyl-thymidin

Guidance literature:: With dimethyl sulfoxide; triethylamine; trichloroacetic acid anhydride; In dichloromethane; at -70 ℃; for 0.5h;
DOI:10.1002/hlca.19960790720

Reference yield:

: 139925-90-9
1-[(2R,4S,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-5-hydroxymethyl-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

: 162052-68-8
3'-O-tert-Butyldimethylsilyl-5'-O-tert-butyldiphenylsilyl-4'-formyl-thymidin

Guidance literature:: Multi-step reaction with 3 steps

1: imidazole / dimethylformamide / 20 °C

2: aq. AcOH / tetrahydrofuran / 20 °C

3: Dess-Martin periodinane / CH₂Cl₂ / 20 °C

With 1H-imidazole; Dess-Martin periodane; acetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(03)01584-3

Reference yield:

: 1-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

: 162052-68-8
3'-O-tert-Butyldimethylsilyl-5'-O-tert-butyldiphenylsilyl-4'-formyl-thymidin

Guidance literature:: Multi-step reaction with 2 steps

1: aq. AcOH / tetrahydrofuran / 20 °C

2: Dess-Martin periodinane / CH₂Cl₂ / 20 °C

With Dess-Martin periodane; acetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0040-4039(03)01584-3