2-(2,4-dichlorophenyl)-1-(4-hydroxyphenyl)-5-methyl-N-(5-(trifluoromethyl)pyridin-2-yl)-1H-imidazole-4-carboxamide

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Chemical Name:2-(2,4-dichlorophenyl)-1-(4-hydroxyphenyl)-5-methyl-N-(5-(trifluoromethyl)pyridin-2-yl)-1H-imidazole-4-carboxamide
CAS No.:866598-60-9
Molecular Formula:C₂₃H₁₅Cl₂F₃N₄O₂
Molecular Weight:507.299
Hs Code.:

Synonyms:2-(2,4-dichlorophenyl)-1-(4-hydroxyphenyl)-5-methyl-N-(5-(trifluoromethyl)pyridin-2-yl)-1H-imidazole-4-carboxamide

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Chemical Property of 2-(2,4-dichlorophenyl)-1-(4-hydroxyphenyl)-5-methyl-N-(5-(trifluoromethyl)pyridin-2-yl)-1H-imidazole-4-carboxamide

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Technology Process of 2-(2,4-dichlorophenyl)-1-(4-hydroxyphenyl)-5-methyl-N-(5-(trifluoromethyl)pyridin-2-yl)-1H-imidazole-4-carboxamide

There total 5 articles about 2-(2,4-dichlorophenyl)-1-(4-hydroxyphenyl)-5-methyl-N-(5-(trifluoromethyl)pyridin-2-yl)-1H-imidazole-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1-(4-(benzyloxy)phenyl)-2-(2,4-dichlorophenyl)-5-methyl-N-(5-(trifluoromethyl)pyridin-2-yl)-1H-imidazole-4-carboxamide

: 866598-60-9
2-(2,4-dichlorophenyl)-1-(4-hydroxyphenyl)-5-methyl-N-(5-(trifluoromethyl)pyridin-2-yl)-1H-imidazole-4-carboxamide

Guidance literature:: 1-(4-(benzyloxy)phenyl)-2-(2,4-dichlorophenyl)-5-methyl-N-(5-(trifluoromethyl)pyridin-2-yl)-1H-imidazole-4-carboxamide; With hydrogen bromide; acetic acid; at 20 ℃; for 4h;

With ammonia;

Reference yield:

: 6574-98-7
2,4-dichlorobenzylnitrile

: 866598-60-9
2-(2,4-dichlorophenyl)-1-(4-hydroxyphenyl)-5-methyl-N-(5-(trifluoromethyl)pyridin-2-yl)-1H-imidazole-4-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: ethylmagnesium bromide / tetrahydrofuran / 0.33 h / Inert atmosphere

1.2: 20 h / 20 °C / Inert atmosphere

2.1: potassium carbonate / tetrahydrofuran / 0.17 h

2.2: 67 h / 20 °C

3.1: trimethylaluminum / toluene; dichloromethane / 1.5 h / 20 °C / Inert atmosphere

3.2: 16 h / 45 °C / Inert atmosphere

4.1: acetic acid; hydrogen bromide / 4 h / 20 °C

With ethylmagnesium bromide; hydrogen bromide; trimethylaluminum; potassium carbonate; acetic acid; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1021/acs.jmedchem.7b00861

Reference yield:

: 866598-55-2
N-(4-(benzyloxy)phenyl)-2,4-dichlorobenzamidine

: 866598-60-9
2-(2,4-dichlorophenyl)-1-(4-hydroxyphenyl)-5-methyl-N-(5-(trifluoromethyl)pyridin-2-yl)-1H-imidazole-4-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / tetrahydrofuran / 0.17 h

1.2: 67 h / 20 °C

2.1: trimethylaluminum / toluene; dichloromethane / 1.5 h / 20 °C / Inert atmosphere

2.2: 16 h / 45 °C / Inert atmosphere

3.1: acetic acid; hydrogen bromide / 4 h / 20 °C

With hydrogen bromide; trimethylaluminum; potassium carbonate; acetic acid; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1021/acs.jmedchem.7b00861