N,N'-((1R,2R)-Cyclohexane-1,2-diyl)bis(N-hydroxy-2,2-diphenylacetamide)

Base Information

Chemical Name:N,N'-((1R,2R)-Cyclohexane-1,2-diyl)bis(N-hydroxy-2,2-diphenylacetamide)
CAS No.:860036-16-4
Molecular Formula:C34H34 N2 O4
Molecular Weight:534.655
Hs Code.:29215900
European Community (EC) Number:635-943-2
DSSTox Substance ID:DTXSID70461826
Nikkaji Number:J2.218.381H
Wikidata:Q76416938
Mol file:860036-16-4.mol

Synonyms:860036-16-4;N,N'-((1R,2R)-Cyclohexane-1,2-diyl)bis(N-hydroxy-2,2-diphenylacetamide);(1R,2R)-N,N'-Dihydroxy-N,N'-bis(diphenylacetyl)cyclohexane-1,2-diamine;N-[(1R,2R)-2-[(2,2-diphenylacetyl)-hydroxyamino]cyclohexyl]-N-hydroxy-2,2-diphenylacetamide;N,N/'-(1R,2R)-1,2-Cyclohexanediylbis[N-hydroxy-alpha-phenylbenzeneacetamide];N,N'-[(1R,2R)-Cyclohexane-1,2-diyl]bis(N-hydroxy-2,2-diphenylacetamide);SCHEMBL3590758;DTXSID70461826;AKOS015856814;CS-W009379;AS-79563;D3715;D90215;(1R,2R)-N,N'-Dihydroxy-N,N'-bis(diphenylacetyl)-1,2-cyclohexanediamine, 97%

Suppliers and Price of N,N'-((1R,2R)-Cyclohexane-1,2-diyl)bis(N-hydroxy-2,2-diphenylacetamide)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TCI Chemical
(1R,2R)-N,N'-Dihydroxy-N,N'-bis(diphenylacetyl)cyclohexane-1,2-diamine
50mg
$ 213.00

Chem-Impex
(1R,2R)-N,N'-Dihydroxy-N,N'-bis(diphenylacetyl)cyclohexane-1,2-diamine,≥98% ≥98%
5G
$ 137.45

American Custom Chemicals Corporation
(1R,2R)-N,N'-DIHYDROXY-N,N'-BIS-(DIPHENYLACETYL)CYCLOHEXANE-1,2-DIAMINE 95.00%
100MG
$ 510.41

AK Scientific
(1R,2R)-N,N'-Dihydroxy-N,N'-bis(diphenylacetyl)cyclohexane-1,2-diamine
50mg
$ 356.00

Total 13 raw suppliers

Chemical Property of N,N'-((1R,2R)-Cyclohexane-1,2-diyl)bis(N-hydroxy-2,2-diphenylacetamide)

Chemical Property:

Melting Point:200-205 °C
Refractive Index:90 ° (C=1, CHCl3)
Boiling Point:727.6±70.0 °C(Predicted)
PKA:8.29±0.40(Predicted)
Flash Point:393.8oC
PSA：81.08000
Density:1.28±0.1 g/cm3(Predicted)
LogP:6.39740
Solubility.:soluble in Chloroform
XLogP3:6.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:8
Exact Mass:534.25185757
Heavy Atom Count:40
Complexity:694

Purity/Quality:

97% ^*data from raw suppliers

(1R,2R)-N,N'-Dihydroxy-N,N'-bis(diphenylacetyl)cyclohexane-1,2-diamine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:T
Statements: 25
Safety Statements: 45

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CCC(C(C1)N(C(=O)C(C2=CC=CC=C2)C3=CC=CC=C3)O)N(C(=O)C(C4=CC=CC=C4)C5=CC=CC=C5)O
Isomeric SMILES:C1CC[C@H]([C@@H](C1)N(C(=O)C(C2=CC=CC=C2)C3=CC=CC=C3)O)N(C(=O)C(C4=CC=CC=C4)C5=CC=CC=C5)O

Technology Process of N,N'-((1R,2R)-Cyclohexane-1,2-diyl)bis(N-hydroxy-2,2-diphenylacetamide)

There total 9 articles about N,N'-((1R,2R)-Cyclohexane-1,2-diyl)bis(N-hydroxy-2,2-diphenylacetamide) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1871-76-7
diphenylacetic acid chloride

: 860036-16-4,1217464-22-6
(R,R)-N-[2-(diphenylacetylhydroxyamino)cyclohexyl]-N-hydroxy-2,2-diphenylacetamide

Guidance literature:: diphenylacetic acid chloride; With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 24 - 72h;

With hydrogenchloride; In methanol; water; for 0.25 - 0.333333h;

Reference yield: 55.0%

: 926018-49-7
C₁₂H₂₆N₂O₂Si

: 1871-76-7
diphenylacetic acid chloride

: 860036-16-4,1217464-22-6
(R,R)-N-[2-(diphenylacetylhydroxyamino)cyclohexyl]-N-hydroxy-2,2-diphenylacetamide

Guidance literature:: C₁₂H₂₆N₂O₂Si; diphenylacetic acid chloride; With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 72h;

With hydrogenchloride; In dichloromethane; for 0.5h; Further stages.;
DOI:10.1016/j.tet.2007.03.071

Reference yield:

: 860036-37-9
C₂₂H₂₆N₂O₄

: 860036-16-4,1217464-22-6
(R,R)-N-[2-(diphenylacetylhydroxyamino)cyclohexyl]-N-hydroxy-2,2-diphenylacetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: benzyloxyhydroxylamine hydrochloride; aq. HCl / methanol / 0.33 h

2.1: 3.85 g / Et₃N; DMAP; imidazole / CH₂Cl₂ / 2 h / 20 °C

3.1: DIEA / CH₂Cl₂ / 72 h

3.2: 55 percent / aq. HCl / CH₂Cl₂ / 0.5 h

With 1H-imidazole; hydrogenchloride; dmap; triethylamine; N-ethyl-N,N-diisopropylamine; benzyloxy-hydroxylamine hydrochloride; In methanol; dichloromethane;
DOI:10.1016/j.tet.2007.03.071