N-α-Fmoc-phospho(1-nitrophenylethyl-2-cyanoethyl)-L-tyrosine tert-butyl ester

Base Information

Chemical Name:N-α-Fmoc-phospho(1-nitrophenylethyl-2-cyanoethyl)-L-tyrosine tert-butyl ester
CAS No.:600173-03-3
Molecular Formula:C₃₉H₄₀N₃O₁₀P
Molecular Weight:741.734
Hs Code.:

Synonyms:N-α-Fmoc-phospho(1-nitrophenylethyl-2-cyanoethyl)-L-tyrosine tert-butyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-α-Fmoc-phospho(1-nitrophenylethyl-2-cyanoethyl)-L-tyrosine tert-butyl ester

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Technology Process of N-α-Fmoc-phospho(1-nitrophenylethyl-2-cyanoethyl)-L-tyrosine tert-butyl ester

There total 3 articles about N-α-Fmoc-phospho(1-nitrophenylethyl-2-cyanoethyl)-L-tyrosine tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 944560-15-0
3-(4-{(2-cyano-ethoxy)-[1-(2-nitro-phenyl)-ethoxy]-phosphanyloxy}-phenyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionic acid tert-butyl ester

: 600173-03-3
N-α-Fmoc-phospho(1-nitrophenylethyl-2-cyanoethyl)-L-tyrosine tert-butyl ester

Guidance literature:: With tert.-butylhydroperoxide; In decane; dichloromethane; at 20 ℃; for 1h;
DOI:10.1021/jo0344891

Reference yield:

: 112883-29-1,92954-90-0
N-Fmoc-Tyr-OH

: 600173-03-3
N-α-Fmoc-phospho(1-nitrophenylethyl-2-cyanoethyl)-L-tyrosine tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 68 percent / CH₂Cl₂; tetrahydrofuran / 20 °C

2: 1H-tetrazole; molecular sieves 4 Angstroem / tetrahydrofuran

3: 442 mg / tert-butyl hydroperoxide / CH₂Cl₂; decane / 1 h / 20 °C

With 1H-tetrazole; tert.-butylhydroperoxide; 4 A molecular sieve; In tetrahydrofuran; decane; dichloromethane;
DOI:10.1021/jo0344891

Reference yield:

: 133852-23-0
tert-butyl (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-hydroxyphenyl)propanoate

: 600173-03-3
N-α-Fmoc-phospho(1-nitrophenylethyl-2-cyanoethyl)-L-tyrosine tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1H-tetrazole; molecular sieves 4 Angstroem / tetrahydrofuran

2: 442 mg / tert-butyl hydroperoxide / CH₂Cl₂; decane / 1 h / 20 °C

With 1H-tetrazole; tert.-butylhydroperoxide; 4 A molecular sieve; In tetrahydrofuran; decane; dichloromethane;
DOI:10.1021/jo0344891