2-amino-9-[4-(4-methoxy-phenoxy)-piperidin-1-yl]-4-phenyl-indeno[1,2-d]pyrimidin-5-one

Base Information

Chemical Name:2-amino-9-[4-(4-methoxy-phenoxy)-piperidin-1-yl]-4-phenyl-indeno[1,2-d]pyrimidin-5-one
CAS No.:1297597-30-8
Molecular Formula:C₂₉H₂₆N₄O₃
Molecular Weight:478.55
Hs Code.:

Synonyms:2-amino-9-[4-(4-methoxy-phenoxy)-piperidin-1-yl]-4-phenyl-indeno[1,2-d]pyrimidin-5-one

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Chemical Property of 2-amino-9-[4-(4-methoxy-phenoxy)-piperidin-1-yl]-4-phenyl-indeno[1,2-d]pyrimidin-5-one

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Technology Process of 2-amino-9-[4-(4-methoxy-phenoxy)-piperidin-1-yl]-4-phenyl-indeno[1,2-d]pyrimidin-5-one

There total 6 articles about 2-amino-9-[4-(4-methoxy-phenoxy)-piperidin-1-yl]-4-phenyl-indeno[1,2-d]pyrimidin-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1296835-93-2
trifluoro-methanesulfonic acid 2-amino-5-oxo-4-phenyl-5H-indeno[1,2-d]pyrimidin-9-yl ester

: 162402-33-7
4-(4-methoxyphenoxy)piperidine

: 1297597-30-8
2-amino-9-[4-(4-methoxy-phenoxy)-piperidin-1-yl]-4-phenyl-indeno[1,2-d]pyrimidin-5-one

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; at 130 ℃; for 7h;

Reference yield:

: 6968-35-0
7-hydroxy-indan-1-one

: 1297597-30-8
2-amino-9-[4-(4-methoxy-phenoxy)-piperidin-1-yl]-4-phenyl-indeno[1,2-d]pyrimidin-5-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / acetone / 6 h / Reflux

2.1: sodium hydroxide / ethanol; water / 1.5 h

3.1: sodium hydroxide / ethanol / 0.5 h

3.2: Reflux

4.1: sodium hydroxide; oxygen / 1-methyl-pyrrolidin-2-one / 16 h / 80 °C

5.1: trifluoroacetic acid / dichloromethane / 2 h

6.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.33 h

6.2: 4 h

7.1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 7 h / 130 °C

With potassium tert-butylate; oxygen; potassium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; In 1-methyl-pyrrolidin-2-one; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone;

Reference yield:

: 1296835-84-1
7-((4-methoxybenzyl)oxy)-2,3-dihydro-1H-inden-1-one

: 1297597-30-8
2-amino-9-[4-(4-methoxy-phenoxy)-piperidin-1-yl]-4-phenyl-indeno[1,2-d]pyrimidin-5-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydroxide / ethanol; water / 1.5 h

2.1: sodium hydroxide / ethanol / 0.5 h

2.2: Reflux

3.1: sodium hydroxide; oxygen / 1-methyl-pyrrolidin-2-one / 16 h / 80 °C

4.1: trifluoroacetic acid / dichloromethane / 2 h

5.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.33 h

5.2: 4 h

6.1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 7 h / 130 °C

With potassium tert-butylate; oxygen; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; In 1-methyl-pyrrolidin-2-one; ethanol; dichloromethane; water; N,N-dimethyl-formamide;